Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833, Taiwan.
Molecules. 2012 Aug 7;17(8):9443-50. doi: 10.3390/molecules17089443.
A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
从台湾产柳珊瑚(Echinomuricea sp.)中分离得到一个新的 clerodane 型二萜，命名为 echinoclerodane A(1)。通过波谱学方法鉴定了其结构。化合物 1 是首次从刺胞动物门的海洋生物中获得的 clerodane 型化合物。化合物 1 对 MOLT-4、HL-60、DLD-1 和 LoVo 肿瘤细胞表现出中等的细胞毒性，并对人中性粒细胞中超氧阴离子的产生和弹性蛋白酶的释放具有抑制作用。
