Department of Animal and Poultry Science, University of Guelph, Guelph, ON, Canada, N1G 2W1.
J Anim Sci. 2012 Dec;90(13):4833-8. doi: 10.2527/jas.2012-5264. Epub 2012 Aug 7.
The objective of the present study was to determine the effects of feeding diets containing grains naturally contaminated with Fusarium mycotoxins to fryer rabbits. The efficacy of a glucomannan mycotoxin adsorbent (GMA) was also examined. Thirty 5-wk-old male New Zealand White rabbits were fed a control diet, a contaminated diet, or a contaminated diet + 0.2% GMA for 21 d. Experimental diets contained deoxynivalenol (DON; vomitoxin) at a concentration of 0.25, 4.3, and 4.9 μg/g, respectively. Feed intake was measured daily and water intake was measured every 3 d. At the end of the feeding period, blood was collected for evaluation of serum chemistry and hematology. Visceral organs were excised, weighed, and processed for histopathological examination. Body weight gain and water intake were greater in rabbits fed the contaminated diet (P = 0.075 and 0.020, respectively) and those fed the contaminated + GMA diet (P = 0.026 and 0.002, respectively) compared with controls. Rabbits fed the contaminated + GMA diet had significantly increased serum urea concentrations (P = 0.023) and decreased serum alkaline phosphatase activity (P = 0.020) compared with controls. Increase in BW gain of rabbits fed the contaminated diets was caused by increased water consumption. There was no effect (P > 0.05) of diet on relative organ weights, but decreased infiltrations with eosinophilic granulocytes were observed in different regions of the intestine in rabbits fed the contaminated or the contaminated + GMA diet. It was concluded that rabbits could be adversely affected by feed-borne Fusarium mycotoxins but appear to be less sensitive than other mammalian species. Supplementation with GMA did not reduce many of the effects of feed-borne mycotoxins.
本研究旨在确定饲喂天然污染镰刀菌霉菌毒素谷物的肉鸡日粮对肉鸡的影响。同时，还研究了葡甘露聚糖霉菌毒素吸附剂（GMA）的功效。将 30 只 5 周龄雄性新西兰白兔分别饲喂对照日粮、污染日粮或污染日粮+0.2%GMA，为期 21 天。试验日粮中脱氧雪腐镰刀菌烯醇（DON；呕吐毒素）的浓度分别为 0.25、4.3 和 4.9μg/g。每天记录采食量，每 3 天记录一次饮水量。在饲养期结束时，采集血液以评估血清生化和血液学指标。采集内脏器官并称重，用于组织病理学检查。与对照组相比，饲喂污染日粮（P=0.075 和 0.020）和污染+GMA 日粮（P=0.026 和 0.002）的兔子体重增加和饮水量增加（P=0.026 和 0.002）。与对照组相比，饲喂污染+GMA 日粮的兔子血清尿素浓度显著升高（P=0.023），血清碱性磷酸酶活性降低（P=0.020）。饲喂污染日粮的兔子体重增加是由于饮水量增加所致。日粮对相对器官重量没有影响（P＞0.05），但在饲喂污染或污染+GMA 日粮的兔子的肠道不同区域观察到嗜酸性粒细胞浸润减少。综上所述，兔子可能会受到饲料源性镰刀菌霉菌毒素的不利影响，但比其他哺乳动物物种的敏感性较低。补充 GMA 并不能减轻饲料源性霉菌毒素的许多影响。
