Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
J Nat Prod. 2012 Aug 24;75(8):1495-9. doi: 10.1021/np300352u. Epub 2012 Aug 8.
Two new dimeric sterols, manadosterols A (1) and B (2), were isolated from the marine sponge Lissodendryx fibrosa collected in Indonesia. The two compounds are comprised of two sulfonated sterol cores connected through the respective side chains. Manadosterols A (1) and B (2) inhibited the Ubc13-Uev1A interaction with IC(50) values of 0.09 and 0.13 μM, respectively. They are the second and third natural compounds showing inhibitory activities against the Ubc13-Uev1A interaction and are more potent than leucettamol A (IC(50), 106 μM), the first such inhibitor, isolated from another marine sponge.
两种新的二聚甾体化合物，manadosterols A（1）和 B（2），从印度尼西亚采集的海洋海绵 Lissodendryx fibrosa 中分离得到。这两种化合物由两个通过各自侧链连接的磺化甾体核心组成。manadosterols A（1）和 B（2）分别以 0.09 和 0.13 μM 的 IC50 值抑制 Ubc13-Uev1A 相互作用。它们是第二种和第三种显示出抑制 Ubc13-Uev1A 相互作用的天然化合物，比从另一种海洋海绵中分离得到的第一个此类抑制剂 leucettamol A（IC50，106 μM）更有效。
