Institute of Genetics, University of Munich, Martinsried, Germany.
Front Plant Sci. 2012 Aug 3;3:181. doi: 10.3389/fpls.2012.00181. eCollection 2012.
Plasma membranes require high levels of plasticity to modulate the perception and transduction of extracellular and intracellular signals. Dynamic lateral assembly of protein complexes combined with an independent compositional lipid patterning in both membrane leaflets provide cells the opportunity to decorate this interface with specific proteins in an organized but dynamic manner. Such ability to dynamically reorganize the protein content of the plasma membrane is essential for the regulation of processes such as polarity of transport, development, and microbial infection. While the plant cell wall represents the first physical and mostly unspecific barrier for invading microbes, the plasma membrane is at the forefront of microbial recognition and initiation of defense responses. Accumulating evidence indicating dynamic compartmentalization of plasma membranes in response to environmental cues has increased the interest in the compositional heterogeneity of this bilayer. Here, we elucidate the recruitment of specific proteins into defined membrane structures that ensure functional compartmentalization of the bilayer during infection processes.
质膜需要高度的可塑性来调节细胞外和细胞内信号的感知和转导。蛋白质复合物的动态侧向组装与两个膜小叶中独立的组成脂质图案相结合，为细胞提供了机会，以有组织但动态的方式用特定的蛋白质来修饰这个界面。这种动态重组质膜蛋白质含量的能力对于调节运输、发育和微生物感染等过程的极性至关重要。虽然植物细胞壁是入侵微生物的第一道物理屏障，且大多数情况下是非特异性的，但质膜是微生物识别和启动防御反应的前沿。越来越多的证据表明，质膜会对环境信号进行动态区隔化，这增加了人们对双层膜组成异质性的兴趣。在这里，我们阐明了特定蛋白质被招募到特定的膜结构中，以确保在感染过程中双层的功能区隔化。
