Departament de Fisicoquímica, Facultat de Farmàcia, Universitat de Barcelona, Avda, Joan XXIII, Barcelona, Catalonia, 08028, Spain.
Nanoscale Res Lett. 2012 Aug 10;7(1):452. doi: 10.1186/1556-276X-7-452.
This study looked at the effect of an external magnet on the biodistribution of magnetoliposomes intravenously administrated in mice (8 mg iron/kg) with and without induced acute inflammation. Our results showed that due to enhanced vascular permeability, magnetoliposomes accumulated at the site of inflammation in the absence of an external magnetic field, but the amount of iron present increased under the effect of a magnet located at the inflammation zone. This increase was dependent on the time (20 or 60 min) of exposure of the external magnetic field. It was also observed that the presence of the magnet was associated with lower amounts of iron in the liver, spleen, and plasma than was found in mice in which a magnet had not been applied. The results of this study confirm that it is possible to target drugs encapsulated in magnetic particles by means of an external magnet.
本研究观察了外加磁场对静脉给予（8mg 铁/公斤）载磁脂质体后有无诱导急性炎症的小鼠的生物分布的影响。我们的结果表明，由于血管通透性增强，载磁脂质体在没有外加磁场的情况下聚集在炎症部位，但在位于炎症区的磁铁的作用下，铁的含量增加。这种增加取决于外加磁场暴露的时间（20 或 60 分钟）。还观察到磁铁的存在与未施加磁铁的小鼠相比，肝脏、脾脏和血浆中的铁含量较低。本研究的结果证实，通过外加磁场可以靶向包裹在磁性颗粒中的药物。
