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复方新诺明对硝苯地平药代动力学和药效学无影响。

Lack of effect of co-trimoxazole on the pharmacokinetics and pharmacodynamics of nifedipine.

作者信息

Edwards C, Monkman S, Cholerton S, Rawlins M D, Idle J R, Ferner R E

机构信息

Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne.

出版信息

Br J Clin Pharmacol. 1990 Dec;30(6):889-91. doi: 10.1111/j.1365-2125.1990.tb05456.x.

DOI:10.1111/j.1365-2125.1990.tb05456.x
PMID:2288835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1368311/
Abstract

The pharmacokinetics of nifedipine and its primary oxidised metabolite, M-I were studied in nine healthy volunteers following a single oral dose of 20 mg nifedipine alone or after pretreatment with oral co-trimoxazole. Following pretreatment with co-trimoxazole, no significant effect was detected on maximum plasma concentration, elimination half-life, or area under the plasma concentration-time curve of either nifedipine or M-I, nor on the blood pressure response to nifedipine.

摘要

在9名健康志愿者中，研究了单次口服20毫克硝苯地平单独用药或口服复方新诺明预处理后硝苯地平及其主要氧化代谢产物M-I的药代动力学。口服复方新诺明预处理后，未检测到对硝苯地平或M-I的最大血浆浓度、消除半衰期、血浆浓度-时间曲线下面积有显著影响，对硝苯地平的血压反应也无显著影响。

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本文引用的文献

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Nephrotoxicity of trimethoprim and cotrimoxazole in renal allograft recipients treated with cyclosporine.甲氧苄啶和复方新诺明在接受环孢素治疗的肾移植受者中的肾毒性。
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Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients.复方新诺明与环孢素对移植患者的肾毒性。
Lancet. 1984 May 5;1(8384):1016-7. doi: 10.1016/s0140-6736(84)92352-3.
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Br J Clin Pharmacol. 1987 Mar;23(3):311-5. doi: 10.1111/j.1365-2125.1987.tb03050.x.
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Determination of nifedipine and its three principal metabolites in plasma and urine by automated electron-capture capillary gas chromatography.采用自动电子捕获毛细管气相色谱法测定血浆和尿液中的硝苯地平及其三种主要代谢物。
J Chromatogr. 1988 Mar 4;425(1):107-19. doi: 10.1016/0378-4347(88)80011-2.
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Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.人P450PCN1：序列、染色体定位以及通过cDNA表达得出的P450PCN1是硝苯地平氧化酶的直接证据。
DNA. 1988 Mar;7(2):79-86. doi: 10.1089/dna.1988.7.79.
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Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.细胞色素P-450 hPCN3，一种在成年人类肝脏中差异表达的新型细胞色素P-450 IIIA基因产物。cDNA及推导的氨基酸序列，以及cDNA表达的hPCN1和hPCN3对甾体激素和环孢素代谢的独特特异性。
J Biol Chem. 1989 Jun 25;264(18):10388-95.
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Interaction between warfarin and sulphamethoxazole.华法林与磺胺甲恶唑之间的相互作用。
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Ann Intern Med. 1979 Jul;91(1):34-6. doi: 10.7326/0003-4819-91-1-34.
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Letter: Potentiation of warfarin by co-trimoxazole.信函：复方新诺明对华法林的增效作用。
Lancet. 1975 Dec 6;2(7945):1155-6. doi: 10.1016/s0140-6736(75)91057-0.