Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie and Centre for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9181-4. doi: 10.1002/anie.201202684. Epub 2012 Aug 13.
Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry.
一种新颖的方法利用光进行肟键合化学。一种定量的、低能量的光脱保护生成醛，随后与氨氧基部分反应。空间控制允许使用氟标记和 GRGSGR 肽在表面上进行图案化，并且可以通过飞行时间二次离子质谱进行成像。
