通过光触发肟键合对生物分子表面进行图案化处理。
(Bio)molecular surface patterning by phototriggered oxime ligation.
机构信息
Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie and Centre for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
出版信息
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9181-4. doi: 10.1002/anie.201202684. Epub 2012 Aug 13.
Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry.
轻结扎
一种新颖的方法利用光进行肟键合化学。一种定量的、低能量的光脱保护生成醛，随后与氨氧基部分反应。空间控制允许使用氟标记和 GRGSGR 肽在表面上进行图案化，并且可以通过飞行时间二次离子质谱进行成像。
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