Department of Dermatology, Medisch Centrum 't Gooi, Bussum, The Netherlands.
Lasers Med Sci. 2013 May;28(3):935-40. doi: 10.1007/s10103-012-1179-z. Epub 2012 Aug 14.
We demonstrate the efficacy of a novel minimally invasive nonthermal skin rejuvenation technique for wrinkle and fine-line reduction based on laser-induced optical breakdown. The optical breakdown caused by tightly focused near-infrared laser pulses creates a grid of intradermal lesions without affecting the epidermis, leading to skin rejuvenation. The pilot in vivo efficacy test performed on five subjects successfully demonstrates wrinkle and fine-line reduction, and improvement of other skin features without pain or any other unpleasant sensations or any social downtime associated with the treatment. The efficacy is evaluated objectively and subjectively by assessing the improvement of wrinkles and/or fine lines or skin texture after the treatment. The treatment is safe without side effects or social downtime, and all test subjects reported that the treatment is "perceptible but not painful." Four out of the five subjects who participated in this pilot study were assessed to have "minor" to "significant" improvements of wrinkles and fine lines by the professional panels. The results of this clinical study are expected to bring a paradigm shift in the present laser- and light-based skin rejuvenation methods by introducing a safe treatment procedure without damaging the epidermis, with no or little social downtime and with an efficacy that might be comparable to ablative techniques.
我们展示了一种基于激光诱导光击穿的新型微创非热皮肤年轻化技术在减少皱纹和细纹方面的疗效。紧密聚焦的近红外激光脉冲引起的光击穿在不影响表皮的情况下在真皮内产生网格状损伤，从而实现皮肤年轻化。在五名受试者中进行的初步体内疗效测试成功地证明了该技术在减轻皱纹和细纹以及改善其他皮肤特征方面的疗效，而且治疗过程无痛，不会带来任何其他不愉快的感觉，也不会影响社交。通过评估治疗后皱纹和/或细纹或皮肤质地的改善情况，可以对疗效进行客观和主观的评估。该治疗方法安全无副作用，也不会影响社交，所有受试者都报告说治疗“可感知但不疼痛”。在这项初步研究中，四名受试者被专业小组评估为皱纹和细纹有“轻微”到“显著”的改善。这项临床研究的结果有望通过引入一种安全的治疗程序，在不损伤表皮的情况下，无需或几乎无需社交时间，并且疗效可与消融技术相媲美，从而改变目前基于激光和光的皮肤年轻化方法。
