Varghese Babu, Bonito Valentina, Jurna Martin, Palero Jonathan, Verhagen Margaret Hortonand Rieko
Department of Personal Care and Wellness, Philips Research, 5656AE, Eindhoven, The Netherlands.
Biomed Opt Express. 2015 Mar 11;6(4):1234-40. doi: 10.1364/BOE.6.001234. eCollection 2015 Apr 1.
We investigated the influence of thermal initiation pathway on the irradiance threshold for laser induced breakdown in transparent, absorbing and scattering phantoms. We observed a transition from laser-induced optical breakdown to laser-induced thermal breakdown as the absorption coefficient of the medium is increased. We found that the irradiance threshold after correction for the path length dependent absorption and scattering losses in the medium is lower due to the thermal pathway for the generation of seed electrons compared to the laser-induced optical breakdown. Furthermore, irradiance threshold gradually decreases with the increase in the absorption properties of the medium. Creating breakdown with lower irradiance threshold that is specific at the target chromophore can provide intrinsic target selectivity and improve safety and efficacy of skin treatment methods that use laser induced breakdown.
我们研究了热引发途径对透明、吸收性和散射性体模中激光诱导击穿辐照阈值的影响。随着介质吸收系数的增加，我们观察到从激光诱导光学击穿到激光诱导热击穿的转变。我们发现，与激光诱导光学击穿相比，由于产生种子电子的热途径，在修正了介质中与路径长度相关的吸收和散射损耗后的辐照阈值更低。此外，辐照阈值随着介质吸收特性的增加而逐渐降低。以较低的辐照阈值产生特定于目标发色团的击穿可以提供内在的目标选择性，并提高使用激光诱导击穿的皮肤治疗方法的安全性和有效性。
