造血干细胞/祖细胞的动员：一般原则和分子机制。
Mobilization of hematopoietic stem/progenitor cells: general principles and molecular mechanisms.
作者信息
Bonig Halvard, Papayannopoulou Thalia
机构信息
Department of Medicine/Hematology, University of Washington, Seattle, WA, USA.
出版信息
Methods Mol Biol. 2012;904:1-14. doi: 10.1007/978-1-61779-943-3_1.
Abstract
Hematopoietic stem/progenitor cell mobilization can be achieved by a variety of bone marrow niche modifications, although efficient mobilization requires simultaneous expansion of the stem/progenitor cell pool and niche modification. Many of the mechanisms involved in G-CSF-induced mobilization have been described. With regard to mobilization of hematopoietic stem/progenitor cells, challenges for the future include the analysis of genetic factors responsible for the great variability in mobilization responses, and the identification of predictors of mobilization efficiency, as well as the development of mobilizing schemes for poor mobilizers. Moreover, improved regimens for enhanced or even preferential mobilization of nonhematopoietic stem/progenitor cell types, and their therapeutic potential for endogenous tissue repair will be questions to be vigorously pursued in the near future.
摘要
造血干/祖细胞动员可通过多种骨髓龛修饰来实现，尽管有效的动员需要同时扩大干/祖细胞池并进行龛修饰。许多与粒细胞集落刺激因子（G-CSF）诱导的动员相关的机制已被描述。关于造血干/祖细胞的动员，未来的挑战包括分析导致动员反应差异巨大的遗传因素、识别动员效率的预测指标，以及为动员效果不佳者制定动员方案。此外，改进方案以增强甚至优先动员非造血干/祖细胞类型，以及它们在内源性组织修复中的治疗潜力，将是在不久的将来需要大力探索的问题。
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