Zacharko R M, Lalonde G T, Kasian M, Anisman H
Department of Psychology, Carleton University, Ottawa, Ont., Canada.
Brain Res. 1987 Nov 17;426(1):164-8. doi: 10.1016/0006-8993(87)90436-7.
Responding for electrical stimulation from the nucleus accumbens was assessed in 3 inbred strains of mice (DBA/2J, C57BL/6J and BALB/cByJ) following exposure to uncontrollable footshock. While the operant response was most readily acquired in the DBA/2J strain, exposure to inescapable shock in this strain induced a marked deterioration of self-stimulation responding, which tended to dissipate over a 168-h period. In contrast to these mice, the stressor did not affect self-stimulation responding in the C57BL/6J strain, and produced a transient enhancement of responding in BALB/cByJ mice. It appears that although uncontrollable aversive events may engender an anhedonic effect, such an outcome is strain-dependent. These data suggest the importance of considering individual and genetic differences in the development of animal models of depression.
在暴露于不可控足部电击后，对3个近交系小鼠（DBA/2J、C57BL/6J和BALB/cByJ）伏隔核的电刺激反应进行了评估。虽然操作性反应在DBA/2J品系中最容易获得，但该品系暴露于不可逃避的电击会导致自我刺激反应显著恶化，这种恶化在168小时内趋于消散。与这些小鼠不同，应激源对C57BL/6J品系的自我刺激反应没有影响，并且在BALB/cByJ小鼠中产生了短暂的反应增强。似乎尽管不可控的厌恶事件可能会产生快感缺失效应，但这种结果是品系依赖性的。这些数据表明在抑郁症动物模型的开发中考虑个体和基因差异的重要性。
