Karádi Z, Oomura Y, Nishino H, Scott T R, Lénárd L, Aou S
Institute of Physiology, University Medical School, Pécs, Hungary.
Brain Res Bull. 1990 Dec;25(6):933-9. doi: 10.1016/0361-9230(90)90191-2.
To elucidate the roles of glucose-sensitive (GS) and glucose-insensitive (GIS) cells of the lateral hypothalamic area (LHA), single neuron activity was recorded during 1) microelectrophoretic administration of chemicals, 2) a conditioned bar press feeding task, 3) gustatory, 4) olfactory, and 5) electrical brain stimulation. GS and GIS neurons showed different firing rate changes during phases of the task, and the responses were highly influenced by the palatability of the food and the motivational (hunger or satiety) state of the animal. The two groups of cells also differed in their responsiveness to gustatory and olfactory stimuli: GS neurons were more likely to respond to tastes and odors than GIS cells. Taste- and odor-responsive GS neurons were primarily suppressed by electrophoretically applied noradrenaline and were localized ventromedially within the LHA. The chemosensitive GIS cells, being organized along a dorsolateral axis, were especially excited by dopamine. The two sets of neurons had distinct connections with associative (orbitofrontal, prefrontal) cortical areas. GS and GIS cells, thus, appear to have differential and complex attributes in the control of feeding.
为阐明下丘脑外侧区（LHA）葡萄糖敏感（GS）和葡萄糖不敏感（GIS）细胞的作用，在以下情况下记录单个神经元活动：1）微量电泳给药化学物质；2）条件性压杆进食任务；3）味觉刺激；4）嗅觉刺激；5）脑电刺激。在任务阶段，GS和GIS神经元表现出不同的放电频率变化，并且这些反应受食物适口性和动物动机（饥饿或饱腹）状态的高度影响。这两组细胞对味觉和嗅觉刺激的反应性也有所不同：GS神经元比GIS细胞更可能对味道和气味作出反应。对味觉和气味有反应的GS神经元主要被电泳施加的去甲肾上腺素抑制，并且位于LHA的腹内侧。沿背外侧轴排列的化学敏感GIS细胞尤其被多巴胺兴奋。这两组神经元与联合（眶额、前额）皮质区域有不同的连接。因此，GS和GIS细胞在进食控制中似乎具有不同且复杂的特性。
