Oomura Y, Nishino H, Karadi Z, Aou S, Scott T R
Department of Biological Control Systems, National Institute for Physiological Sciences, Okazaki, Japan.
Physiol Behav. 1991 May;49(5):943-50. doi: 10.1016/0031-9384(91)90207-5.
Single neuron activity in the monkey lateral hypothalamus (LHA) was recorded by multibarreled electrode during a bar press feeding task. Activity of glucose-sensitive (GS) neurons decreased during bar press (BP) and reward (RW) periods. The inhibition was caused by activation of beta-adrenoceptors and opioid receptors respectively. Glucose-insensitive (GIS) neurons were excited during BP and RW, and at cue light (CL). Excitation at CL and BP was caused by activation of dopaminergic receptors. Among GS neurons, 66% responded to taste and 88% to odor. These responses were 39% and 52% in GIS neurons. GS neurons responded predominantly to two or more taste and odor stimuli while GIS neurons responded to only one stimulant. GS neurons have dense mutual connections with the prefrontal area, and GIS neurons are connected with the motor area. Gustatory and olfactory stimulation elicited responses in 67% of GS neurons and in only 21% of GIS neurons. Data suggest that GS and GIS neurons may have different functions in feeding: GS neurons process endogenous chemical information and integrated chemical sensations, and GIS neurons process external information processing, motor control and discriminative chemical sensations.
在一项压杆进食任务中，使用多管电极记录了猴子外侧下丘脑（LHA）中的单个神经元活动。在压杆（BP）和奖励（RW）期间，葡萄糖敏感（GS）神经元的活动减少。这种抑制分别是由β-肾上腺素能受体和阿片受体的激活引起的。葡萄糖不敏感（GIS）神经元在BP、RW以及提示光（CL）出现时被兴奋。CL和BP时的兴奋是由多巴胺能受体的激活引起的。在GS神经元中，66%对味觉有反应，88%对气味有反应。在GIS神经元中，这些反应分别为39%和52%。GS神经元主要对两种或更多种味觉和气味刺激产生反应，而GIS神经元仅对一种刺激产生反应。GS神经元与前额叶区域有密集的相互连接，而GIS神经元与运动区域相连。味觉和嗅觉刺激在67%的GS神经元中引发反应，而在仅21%的GIS神经元中引发反应。数据表明，GS和GIS神经元在进食过程中可能具有不同的功能：GS神经元处理内源性化学信息和整合化学感觉，而GIS神经元处理外部信息处理、运动控制和辨别性化学感觉。
