Karádi Z, Oomura Y, Nishino H, Aou S
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Physiol Behav. 1989 Jun;45(6):1249-57. doi: 10.1016/0031-9384(89)90117-0.
The activity of glucose-sensitive (GS) and glucose-insensitive (GIS) neurons was recorded in the lateral hypothalamic area (LHA) of monkeys during olfactory stimulation, a conditioned alimentary bar press task, and microelectrophoretic application of catecholamines. Olfactory stimuli evoked response of 88% of the GS neurons, and 52% of the GIS cells responded to odors. The GS neurons were more broadly tuned across odorants than the GIS cells, and their responses to various smells with distinct hedonic value were also differential. The odor-responding GS neurons were depressed during the bar press and reward periods of the task, and were mainly inhibited by dopamine. The odor-responding GIS cell activity increased in response to cue light and tone, and was facilitated by dopamine. Histological examinations disclosed topographic dissociation of the odor-responding GS and GIS cells: the former were located in more ventromedial regions than the latter. The results indicate that the GS neurons integrate multiple chemosensory inputs from both endogenous and exogenous sources in the regulation of feeding: whereas the GIS cells distinguish among fewer, more specific cues to control food acquisition behavior.
在猴子的外侧下丘脑区域（LHA）记录葡萄糖敏感（GS）和葡萄糖不敏感（GIS）神经元的活动，记录过程包括嗅觉刺激、条件性食物按压杠杆任务以及儿茶酚胺的微电泳应用。嗅觉刺激诱发了88%的GS神经元产生反应，52%的GIS细胞对气味有反应。与GIS细胞相比，GS神经元对各种气味的调谐范围更广，并且它们对具有不同享乐价值的各种气味的反应也有所不同。在任务的按压杠杆和奖励期间，对气味有反应的GS神经元受到抑制，并且主要被多巴胺抑制。对气味有反应的GIS细胞活动在对提示光和音调产生反应时增加，并被多巴胺促进。组织学检查揭示了对气味有反应的GS和GIS细胞的地形分离：前者比后者位于更腹内侧区域。结果表明，GS神经元在内源性和外源性多种化学感觉输入的整合中对进食进行调节：而GIS细胞区分较少、更特定的线索以控制食物获取行为。
