Medicinal Plants Research Center, Federal University of Piauí, Teresina, Brazil.
J Med Food. 2012 Nov;15(11):984-91. doi: 10.1089/jmf.2012.0102. Epub 2012 Aug 14.
This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities of carvacrol, a phenolic monoterpene constituent of essential oils produced by oregano and other several aromatic plants and spices, in experimental models of edema induced by different phlogistic agents and gastric lesions induced by acetic acid. In models of paw edema induced by dextran or histamine, carvacrol was effective at 50 mg/kg (46% and 35%, respectively); in these models, cyproheptadine reduced edema formation (61% and 43%, respectively). In edema induced by substance P, carvacrol (100 mg/kg) and ruthenium red (3 mg/kg) also decreased the edema formation (46% and 40%, respectively). Carvacrol significantly reduced the ear edema induced by 12-O-tetradecanoylphorbol acetate and arachidonic acid at 0.1 mg per ear (43% and 33%, respectively), similar to indomethacin at 0.5 mg per ear or 2.0 mg per ear (55% and 57%, respectively). Carvacrol (at doses of 25, 50, and 100 mg/kg) showed a healing capacity on gastric lesions induced by acid acetic (60%, 91%, and 81%, respectively) after 14 days of treatment. These results suggest that carvacrol acts on different pharmacological targets, probably interfering in release and/or synthesis of inflammatory mediators, such as the prostanoids, and thus favoring the healing process for gastric ulcers.
本研究报告了香芹酚（一种存在于牛至和其他几种芳香植物和香料的精油中的酚类单萜）在不同致炎剂诱导的水肿模型和乙酸诱导的胃损伤模型中的抗炎和抗溃疡活性的药理学评价。在葡聚糖或组胺诱导的爪水肿模型中，香芹酚在 50mg/kg 时有效（分别为 46%和 35%）；在这些模型中，赛庚啶抑制水肿形成（分别为 61%和 43%）。在 P 物质诱导的水肿中，香芹酚（100mg/kg）和钌红（3mg/kg）也减少了水肿形成（分别为 46%和 40%）。香芹酚显著减少了 12-O-十四烷酰佛波醇乙酸酯和花生四烯酸诱导的耳水肿（分别为 43%和 33%），与吲哚美辛在 0.5mg/耳或 2.0mg/耳时的效果相似（分别为 55%和 57%）。香芹酚（剂量为 25、50 和 100mg/kg）在酸乙酸诱导的胃损伤 14 天后显示出愈合能力（分别为 60%、91%和 81%）。这些结果表明，香芹酚作用于不同的药理靶点，可能干扰前列腺素等炎症介质的释放和/或合成，从而有利于胃溃疡的愈合过程。
