Guangdong Provincial Key Laboratory of Stomatology and School of Stomatology, Sun Yat-sen University, Guangzhou, China.
J Dent. 2012 Nov;40(11):962-7. doi: 10.1016/j.jdent.2012.08.002. Epub 2012 Aug 11.
To compare the effectiveness of annual topical application of silver diamine fluoride (SDF) solution, semi-annual topical application of SDF solution, and annual application of a flowable high fluoride-releasing glass ionomer in arresting active dentine caries in primary teeth.
A total of 212 children, aged 3-4 years, were randomly allocated to one of three groups for treatment of carious dentine cavities in their primary teeth: Gp1-annual application of SDF, Gp2-semi-annual application of SDF, and Gp3-annual application of glass ionomer. Follow-up examinations were carried out every six months to assess whether the treated caries lesions had become arrested.
After 24 months, 181 (85%) children remained in the study. The caries arrest rates were 79%, 91% and 82% for Gp1, Gp2 and Gp3, respectively (p=0.007). In the logistic regression model using GEE to adjust for clustering effect, higher caries arrest rates were found in lesions treated in Gp2 (OR=2.98, p=0.007), those in anterior teeth (OR=5.55, p<0.001), and those in buccal/lingual smooth surfaces (OR=15.6, p=0.004).
Annual application of either SDF solution or high fluoride-releasing glass ionomer can arrest active dentine caries. Increasing the frequency of application to every 6 months can increase the caries arrest rate of SDF application.
Arrest of active dentine caries in primary teeth by topical application of SDF solution can be enhanced by increasing the frequency of application from annually to every 6 months, whereas annual paint-on of a flowable glass ionomer can also arrest active dentine caries and may provide a more aesthetic outcome.
比较每年使用一次银胺氟（SDF）溶液、每半年使用一次 SDF 溶液和每年使用一次流动性高氟释放玻璃离子体治疗乳牙活跃性牙本质龋的效果。
将 212 名 3-4 岁的儿童随机分为三组，用 SDF 溶液治疗其乳牙的龋坏牙本质窝洞：Gp1-每年应用 SDF、Gp2-每半年应用 SDF、Gp3-每年应用玻璃离子体。每六个月进行一次随访检查，以评估治疗后的龋损是否已停止进展。
24 个月后，181 名（85%）儿童仍在研究中。Gp1、Gp2 和 Gp3 的龋齿抑制率分别为 79%、91%和 82%（p=0.007）。在使用 GEE 进行聚类效应调整的逻辑回归模型中，发现 Gp2 治疗的病变（OR=2.98，p=0.007）、前牙（OR=5.55，p<0.001）和颊/舌面光滑表面（OR=15.6，p=0.004）的龋齿抑制率更高。
每年应用 SDF 溶液或高氟释放玻璃离子体均可抑制活跃性牙本质龋。将应用频率增加到每 6 个月一次，可以提高 SDF 应用的龋齿抑制率。
通过增加 SDF 溶液的应用频率（从每年一次增加到每 6 个月一次），可以增强 SDF 溶液局部应用对乳牙活跃性牙本质龋的抑制作用，而每年涂覆流动性玻璃离子体也可以抑制活跃性牙本质龋，并且可能提供更美观的效果。
