Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Hypertension Unit, Heart Institute (InCor), Sao Paulo/SP, Brazil.
Clinics (Sao Paulo). 2012 Jul;67(7):815-20. doi: 10.6061/clinics/2012(07)18.
High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations.
Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p<0.05.
Fructose overload induced a metabolic syndrome state, as confirmed by insulin resistance (F: 3.6 ± 0.2 vs. C: 4.5 ± 0.2 mg/dl/min), hypertension (mean blood pressure, F: 118 ± 3 vs. C: 104 ± 4 mmHg) and obesity (F: 0.31 ± 0.001 vs. C: 0.29 ± 0.001 g/mm). Interestingly, fructose overload rats also exhibited diastolic dysfunction. Exercise training performed during the period of high fructose intake eliminated all of these derangements. The improvements in metabolic parameters were correlated with the maintenance of diastolic function.
The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome.
高果糖摄入会导致代谢综合征的发生，从而导致心血管疾病的发生。我们研究了运动训练是否可以预防高果糖饮食引起的代谢和心脏形态功能改变。
给予 Wistar 大鼠高果糖负荷（在饮用水中 100g/L），同时在跑步机上进行 10 周的训练（FT）或保持久坐。将这些大鼠与对照组（C）进行比较。肥胖通过 Lee 指数评估，血糖和胰岛素耐量试验构成代谢评估。血压通过 Windaq（2kHz）直接测量，超声心动图用于确定左心室形态和功能。通过单向方差分析确定统计学意义，显著性水平设为 p<0.05。
果糖负荷导致代谢综合征状态，如胰岛素抵抗（F：3.6 ± 0.2 vs. C：4.5 ± 0.2mg/dl/min）、高血压（平均血压，F：118 ± 3 vs. C：104 ± 4mmHg）和肥胖（F：0.31 ± 0.001 vs. C：0.29 ± 0.001g/mm）所证实。有趣的是，果糖负荷大鼠还表现出舒张功能障碍。在高果糖摄入期间进行的运动训练消除了所有这些异常。代谢参数的改善与舒张功能的维持相关。
运动训练在预防代谢和血液动力学参数改变中的作用对于降低与代谢综合征相关的心脏发病率和死亡率非常重要。
