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创伤愈合与苯二氮䓬类药物：睡眠在这其中是否发挥了作用？

Wound-healing and benzodiazepines: does sleep play a role in this relationship?

机构信息

Universidade Federal de São Paulo, Departamento de Psicobiologia, São Paulo/SP, Brazil.

出版信息

Clinics (Sao Paulo). 2012 Jul;67(7):827-30. doi: 10.6061/clinics/2012(07)20.

DOI:10.6061/clinics/2012(07)20
PMID:22892930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3400176/
Abstract

Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation.

摘要

烧伤患者常经历心理后果，其中焦虑症较为突出。苯二氮䓬类药物常用于治疗这些症状。苯二氮䓬类药物对愈合的影响可能不是直接的，而是通过改变睡眠结构来调节。这一假说得到了一些研究的支持，这些研究表明，苯二氮䓬类药物在正常睡眠和睡眠剥夺（特别是快速眼动睡眠剥夺）期间对免疫系统和炎症特征的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88fd/3400176/eac0d42adfd2/cln-67-07-827-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88fd/3400176/eac0d42adfd2/cln-67-07-827-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88fd/3400176/eac0d42adfd2/cln-67-07-827-g001.jpg

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本文引用的文献

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The burn wound inflammatory response is influenced by midazolam.烧伤创面炎症反应受咪达唑仑影响。
Inflammation. 2012 Feb;35(1):259-70. doi: 10.1007/s10753-011-9313-9.
2
Prevalence and co-morbidity of psychiatric disorders 1-4 years after burn.烧伤后 1-4 年内精神障碍的患病率和共病情况。
Burns. 2011 Aug;37(5):753-61. doi: 10.1016/j.burns.2010.12.018. Epub 2011 Feb 22.
3
The impact of psychological stress on wound healing: methods and mechanisms.心理压力对伤口愈合的影响：方法和机制。
Hernia. 2018 Oct;22(5):753-757. doi: 10.1007/s10029-018-1766-4. Epub 2018 Mar 28.
4
Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation.在睡眠剥夺的 48 小时内，抑制小胶质细胞的激活可改善大鼠海马体的空间记忆和成年神经发生。
J Neuroinflammation. 2017 Nov 15;14(1):222. doi: 10.1186/s12974-017-0998-z.
5
Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas.细菌转位蛋白（TSPO）的结构与功能关系：聚焦于假单胞菌属
Front Microbiol. 2014 Nov 19;5:631. doi: 10.3389/fmicb.2014.00631. eCollection 2014.
Immunol Allergy Clin North Am. 2011 Feb;31(1):81-93. doi: 10.1016/j.iac.2010.09.010.
4
Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers.健康男性志愿者选择性快速眼动或完全睡眠剥夺后的免疫改变。
Innate Immun. 2012 Feb;18(1):44-54. doi: 10.1177/1753425910385962. Epub 2010 Nov 18.
5
Basics in nutrition and wound healing.营养与伤口愈合基础
Nutrition. 2010 Sep;26(9):862-6. doi: 10.1016/j.nut.2010.05.008.
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Factors affecting wound healing.影响伤口愈合的因素。
J Dent Res. 2010 Mar;89(3):219-29. doi: 10.1177/0022034509359125. Epub 2010 Feb 5.
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J Burn Care Res. 2010 Jan-Feb;31(1):1-12. doi: 10.1097/BCR.0b013e3181cb8e82.
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