血压及其他因素与视网膜小动脉直径随时间的系列测量值之间的关系：比弗迪姆眼研究
Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study.
作者信息
Klein Ronald, Myers Chelsea E, Knudtson Michael D, Lee Kristine E, Gangnon Ronald, Wong Tien Y, Klein Barbara E K
机构信息
Department of Ophthalmology & Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, 417 WARF, Madison, WI 53726, USA.
出版信息
Arch Ophthalmol. 2012 Aug;130(8):1019-27. doi: 10.1001/archophthalmol.2012.560.
OBJECTIVE
To describe the relationship of blood pressure (BP), antihypertensive medication use, and other factors to serial measurements of retinal arteriolar diameters over time in the Beaver Dam Eye Study.
METHODS
Retinal arteriolar diameter was measured by computer-assisted methods and summarized as central retinal arteriolar equivalent (CRAE) in 4573 persons aged 43 to 99 years at 4 examinations (each separated by 5 years) during a 15-year period. Associations of CRAE with risk factors measured concurrently and 5 years previously were determined using multivariate analyses.
RESULTS
While adjusting for image quality, refraction, and lens status, age (per 10 years: β estimate, -0.73; P < .001), systolic BP (per 10 mm Hg: concurrent examination, -2.74; P < .001; previous examination, -1.75; P < .001), smoking status (smoker vs nonsmoker: concurrent examination, 4.29; P < .001; previous examination, 1.63; P = .004), body mass index (per category: concurrent examination, -0.51; P = .05; previous examination, -0.22; P = .44), and heavy alcohol consumption (drinking) (current vs past/never heavy drinker: concurrent examination, -2.54; P = .03; previous examination, -2.42; P = .02) were associated with CRAE. In the same model, there were significant interactions between concurrent and previous systolic BP (0.11; P = .003) and between concurrent and previous body mass index (0.12; P = .04). Use of calcium channel blockers at both the concurrent and past examination (vs neither examination, 1.59; P = .01), but not other classes of antihypertensive drugs, was associated with CRAE.
CONCLUSIONS
Retinal arteriolar diameter is independently associated with past and current systolic BP, calcium channel blocker use, smoking status, body mass index, and heavy drinking during 5-year intervals. The relationships with CRAE are stronger for concurrent than for past measures of these variables.
目的
在比弗迪姆眼研究中，描述血压（BP）、抗高血压药物使用及其他因素与视网膜小动脉直径随时间的系列测量值之间的关系。
方法
在15年期间，通过计算机辅助方法测量4573名年龄在43至99岁的人的视网膜小动脉直径，并将其总结为视网膜中央动脉等效值（CRAE），共进行4次检查（每次间隔5年）。使用多变量分析确定CRAE与同时测量的以及5年前测量的危险因素之间的关联。
结果
在调整图像质量、屈光和晶状体状态后，年龄（每10岁：β估计值，-0.73；P <.001）、收缩压（每10 mmHg：同时检查时，-2.74；P <.001；之前检查时，-1.75；P <.001）、吸烟状况（吸烟者与非吸烟者：同时检查时，4.29；P <.001；之前检查时，1.63；P =.004）、体重指数（每类别：同时检查时，-0.51；P =.05；之前检查时，-0.22；P =.44）和大量饮酒（当前与过去/从不大量饮酒者：同时检查时，-2.5；P =.03；之前检查时，-2.42；P =.02）与CRAE相关。在同一模型中，同时和之前的收缩压之间（0.11；P =.003）以及同时和之前的体重指数之间（0.12；P =.04）存在显著交互作用。在同时和过去检查时使用钙通道阻滞剂（与两次检查均未使用相比，1.59；P =.01），而非其他类别的抗高血压药物，与CRAE相关。
结论
视网膜小动脉直径与过去和当前的收缩压、钙通道阻滞剂使用、吸烟状况、体重指数以及5年间隔期间的大量饮酒独立相关。这些变量与CRAE的关系在同时测量时比过去测量时更强。
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