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关于射波刀虹膜准直器小射野的输出因子测量:微电离室和二极管探测器的k(Q(clin),Q(msr) ) (f(clin),f(msr) )校正因子的实验测定

On the output factor measurements of the CyberKnife iris collimator small fields: Experimental determination of the k(Q(clin),Q(msr) ) (f(clin),f(msr) ) correction factors for microchamber and diode detectors.

作者信息

Pantelis E, Moutsatsos A, Zourari K, Petrokokkinos L, Sakelliou L, Kilby W, Antypas C, Papagiannis P, Karaiskos P, Georgiou E, Seimenis I

机构信息

Medical Physics Laboratory, Medical School, University of Athens, 75 Mikras Asias, 115 27 Athens, Greece.

出版信息

Med Phys. 2012 Aug;39(8):4875-85. doi: 10.1118/1.4736810.

Abstract

PURPOSE

To measure the output factors (OFs) of the small fields formed by the variable aperture collimator system (iris) of a CyberKnife (CK) robotic radiosurgery system, and determine the k(Q(clin),Q(msr) ) (f(clin),f(msr) ) correction factors for a microchamber and four diode detectors.

METHODS

OF measurements were performed using a PTW PinPoint 31014 microchamber, four diode detectors (PTW-60017, -60012, -60008, and the SunNuclear EDGE detector), TLD-100 microcubes, alanine dosimeters, EBT films, and polymer gels for the 5 mm, 7.5 mm, 10 mm, 12.5 mm, and 15 mm iris collimators at 650 mm, 800 mm, and 1000 mm source to detector distance (SDD). The alanine OF measurements were corrected for volume averaging effects using the 3D dose distributions registered in polymer gel dosimeters. k(Q(clin),Q(msr) ) (f(clin),f(msr) ) correction factors for the PinPoint microchamber and the diode dosimeters were calculated through comparison against corresponding polymer gel, EBT, alanine, and TLD results.

RESULTS

Experimental OF results are presented for the array of dosimetric systems used. The PinPoint microchamber was found to underestimate small field OFs, and a k(Q(clin),Q(msr) ) (f(clin),f(msr) ) correction factor ranging from 1.127 ± 0.022 (for the 5 mm iris collimator) to 1.004 ± 0.010 (for the 15 mm iris collimator) was determined at the reference SDD of 800 mm. The PinPoint k(Q(clin),Q(msr) ) (f(clin),f(msr) ) correction factor was also found to increase with decreasing SDD; k(Q(clin),Q(msr) ) (f(clin),f(msr) ) values equal to 1.220 ± 0.028 and 1.077 ± 0.016 were obtained for the 5 mm iris collimator at 650 mm and 1000 mm SDD, respectively. On the contrary, diode detectors were found to overestimate small field OFs and a correction factor equal to 0.973 ± 0.006, 0.954 ± 0.006, 0.937 ± 0.007, and 0.964 ± 0.006 was measured for the PTW-60017, -60012, -60008 and the EDGE diode detectors, respectively, for the 5 mm iris collimator at 800 mm SDD. The corresponding correction factors for the 15 mm iris collimator were found equal to 0.997 ± 0.010, 0.994 ± 0.009, 0.988 ± 0.010, and 0.986 ± 0.010, respectively. No correlation of the diode k(Q(clin),Q(msr) ) (f(clin),f(msr) ) correction factors with SDD was observed.

CONCLUSIONS

This work demonstrates an experimental procedure for the determination of the k(Q(clin),Q(msr) ) (f(clin),f(msr) ) correction factors required to obtain small field OF results of increased accuracy.

摘要

目的

测量射波刀(CK)机器人放射外科系统的可变孔径准直器系统(虹膜式准直器)形成的小射野的输出因子(OFs),并确定微电离室和四个二极管探测器的k(Q(clin),Q(msr) ) (f(clin),f(msr) )校正因子。

方法

使用PTW PinPoint 31014微电离室、四个二极管探测器(PTW - 60017、 - 60012、 - 60008和SunNuclear EDGE探测器)、TLD - 100微立方体、丙氨酸剂量仪、EBT胶片和聚合物凝胶,在源到探测器距离(SDD)为650 mm、800 mm和1000 mm时,对5 mm、7.5 mm、10 mm、12.5 mm和15 mm的虹膜式准直器进行OF测量。使用聚合物凝胶剂量仪中记录的三维剂量分布对丙氨酸OF测量进行体积平均效应校正。通过与相应的聚合物凝胶、EBT、丙氨酸和TLD结果比较,计算PinPoint微电离室和二极管剂量仪的k(Q(clin),Q(msr) ) (f(clin),f(msr) )校正因子。

结果

给出了所使用的剂量测量系统阵列的实验OF结果。发现PinPoint微电离室低估了小射野OFs,在800 mm的参考SDD下,确定的k(Q(clin),Q(msr) ) (f(clin),f(msr) )校正因子范围为1.127±0.022(对于5 mm虹膜式准直器)至1.004±0.010(对于15 mm虹膜式准直器)。还发现PinPoint k(Q(clin),Q(msr) ) (f(clin),f(msr) )校正因子随SDD减小而增加;对于5 mm虹膜式准直器,在650 mm和1000 mm SDD时,k(Q(clin),Q(msr) ) (f(clin),f(msr) )值分别为1.220±0.028和1.077±0.016。相反,发现二极管探测器高估了小射野OFs,对于800 mm SDD下的5 mm虹膜式准直器,PTW - 60017、 - 60012、 - 60008和EDGE二极管探测器测量的校正因子分别为0.973±0.006、0.954±0.006、0.937±0.0

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