Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri 63130, USA.
J Biomed Opt. 2012 Jul;17(7):076012. doi: 10.1117/1.JBO.17.7.076012.
With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.
随着小动物在人类疾病研究中的应用越来越广泛，小动物全身分子成像在生物医学研究中发挥着重要作用。目前，现有的任何一种成像方式都无法同时提供解剖学和葡萄糖分子信息，这导致了构建双模系统的成本更高。即使进行图像配准，分子成像方式的空间分辨率也无法得到提高。利用环形共聚焦光声计算机断层成像系统，我们首次证明，单一模态可以同时进行解剖成像和葡萄糖摄取成像。解剖学成像采用内源性血红蛋白对比，葡萄糖代谢成像采用近红外染料标记的 2-脱氧葡萄糖。
