innoFSPEC Potsdam, Leibniz Institute for Astrophysics Potsdam, Potsdam, Germany.
innoFSPEC Potsdam, University of Potsdam-Physical Chemistry, Potsdam, Germany.
J Biomed Opt. 2018 Oct;23(10):1-11. doi: 10.1117/1.JBO.23.10.105001.
Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed.
成像拉曼光谱可用于识别癌组织。传统上，需要对样品进行逐步扫描以生成拉曼图像，但对于患者的常规检查来说速度太慢。通过将积分场光谱技术（IFS）从天文学转移到拉曼成像，就有可能在单次曝光内快速记录整个拉曼图像，而无需繁琐的扫描过程。本文提出了一种基于 IFS 的拉曼成像系统，能够对离体或体内皮肤进行测量。本文演示了如何记录和分析健康和癌性皮肤活检的拉曼图像。
