(IPr)Ni(allyl)Cl 催化杂芳基氯化物和芳基醚的 Kumada-Tamao-Corriu 偶联反应。
Kumada-Tamao-Corriu coupling of heteroaromatic chlorides and aryl ethers catalyzed by (IPr)Ni(allyl)Cl.
机构信息
Laboratorio de Catálisis Homogénea, Departamento de Química y Ciencias de los Materiales, Unidad Asociada al CSIC, Centro de Investigación en Química Sostenible (CIQSO), Campus de El Carmen s/n, Universidad de Huelva, 21007-Huelva, Spain.
出版信息
Org Lett. 2012 Sep 7;14(17):4318-21. doi: 10.1021/ol302112q. Epub 2012 Aug 15.
The complex (IPr)Ni(allyl)Cl (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazolidene) catalyzes the cross-coupling reactions of heteroaromatic chlorides with aryl Grignard reagents. Catalyst loadings as low as 0.1 mol % have been used to afford the products in excellent yields. This nickel-based catalytic system also promotes the activation of the C(Ar)-O bond of anisoles in the Kumada-Tamao-Corriu reaction under fairly mild conditions.
配合物(IPr)Ni(烯丙基)Cl（IPr=1,3-双(2,6-二异丙基苯基)咪唑烷二烯）可以催化杂芳基氯与芳基格氏试剂的交叉偶联反应。使用低至 0.1mol%的催化剂负载量即可获得优异收率的产物。该镍基催化体系还可以在相当温和的条件下促进 Kumada-Tamao-Corriu 反应中苯甲醚的 C(Ar)-O 键的活化。
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