钯（II）催化吡啶与（杂）芳烃的C3选择性芳基化反应
Pd(II)-Catalyzed C3-Selective Arylation of Pyridine with (Hetero)arenes.
作者信息
Gao Guo-Lin, Xia Wujiong, Jain Pankaj, Yu Jin-Quan
机构信息
Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
The Academy of Fundamental and Interdisciplinary Science, Harbin Institute of Technology , Harbin 150080, China.
出版信息
Org Lett. 2016 Feb 19;18(4):744-7. doi: 10.1021/acs.orglett.5b03712. Epub 2016 Feb 2.
Abstract
Palladium catalyzed, nondirected C3-selective arylation of pyridines with arenes and heteroarenes in the presence of 1,10-phenanthroline as the ligand has been developed. The optimized conditions allow for a highly C3-selective arylation of pyridines, affording various 3,3'-bipyridines and 3-arylpyridines.
摘要
已开发出在1,10-菲咯啉作为配体存在下，钯催化吡啶与芳烃和杂芳烃进行非定向C3选择性芳基化反应。优化后的条件可实现吡啶的高度C3选择性芳基化，得到各种3,3'-联吡啶和3-芳基吡啶。
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