Medical Engineering Department, College of Engineering, Nahrain University, Baghdad, Iraq.
Lasers Med Sci. 2013 May;28(3):941-5. doi: 10.1007/s10103-012-1182-4. Epub 2012 Aug 16.
The effect of wound illumination time by pulsed diode laser on the wound healing process was studied in this paper. For this purpose, the original electronic drive circuit of a 650-nm wavelength CW diode laser was reconstructed to give pulsed output laser of 50 % duty cycle and 1 MHz pulse repetition frequency. Twenty male mice, 3 months old were used to follow up the laser photobiostimulation effect on the wound healing progress. They were subdivided into two groups and then the wounds were made on the bilateral back sides of each mouse. Two sessions of pulsed laser therapy were carried along 15 days. Each mice group wounds were illuminated by this pulsed laser for 12 or 18 min per session during these 12 days. The results of this study were compared with the results of our previous wound healing therapy study by using the same type of laser. The mice wounds in that study received only 5 min of illumination time therapy in the first and second days of healing process. In this study, we found that the wounds, which were illuminated for 12 min/session healed in about 3 days earlier than those which were illuminated for 18 min/session. Both of them were healed earlier in about 10-11 days than the control group did.
本研究旨在探讨脉冲二极管激光对伤口愈合过程中光照时间的影响。为此，我们对原始的 650nm 波长连续波二极管激光的电子驱动电路进行了重构，以获得 50%占空比和 1MHz 脉冲重复频率的脉冲输出激光。我们使用 20 只 3 个月大的雄性小鼠来跟踪激光对伤口愈合过程的光生物刺激作用。将这些小鼠分为两组，然后在每组小鼠的双侧背部制造伤口。在 15 天的时间里，我们进行了两次脉冲激光治疗。在这 12 天里，每组的每个小鼠的伤口都用这种脉冲激光照射 12 或 18 分钟。我们将这些结果与我们之前使用相同类型激光进行的伤口愈合治疗研究的结果进行了比较。在那项研究中，小鼠的伤口在前两天的愈合过程中只接受了 5 分钟的光照治疗。在这项研究中，我们发现，每次照射 12 分钟的伤口比每次照射 18 分钟的伤口提前约 3 天愈合。与对照组相比，它们都提前约 10-11 天愈合。
