糖尿病足溃疡伤口愈合的光生物调节疗法优化及…… （原文结尾不完整）
Optimization of photo-biomodulation therapy for wound healing of diabetic foot ulcers and .
作者信息
Chen Qianqian, Yang Jichun, Yin Huijuan, Li Yingxin, Qiu Haixia, Gu Ying, Yang Hua, Xiaoxi Dong, Xiafei Shi, Che Bochen, Li Hongxiao
机构信息
Laboratory of Laser Medicine, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China.
National Research Center for Rehabilitation Technical Aids, Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, Key Laboratory of Human Motion Analysis and Rehabilitation Technology of the Ministry of Civil Affairs, Beijing 100176, China.
出版信息
Biomed Opt Express. 2022 Mar 25;13(4):2450-2466. doi: 10.1364/BOE.451135. eCollection 2022 Apr 1.
Unclear optical parameters make photo-biomodulation (PBM) difficult to implement in diabetic foot ulcer (DFU) clinically. Here, 12 wavelengths (400-900 nm) were used to conduct PBM to heal DFU wounds in vitro and in vivo. PBM at 10 mW/cm and 0.5-4 J/cm with all 12 wavelengths promoted proliferation of diabetic wound cells. In a mimic DFU (mDFU) rat model, PBM (425, 630, 730, and 850 nm, and a combination light strategy) promoted mDFU healing. The positive cell proliferation, re-epithelialization, angiogenesis, collagen synthesis, and inflammation were possible mechanisms. The combination strategy had the best effect, which can be applied clinically.
不明确的光学参数使得光生物调节（PBM）在临床上难以应用于糖尿病足溃疡（DFU）。在此，使用12种波长（400 - 900 nm）进行PBM以在体外和体内促进DFU伤口愈合。所有12种波长在10 mW/cm和0.5 - 4 J/cm条件下的PBM均促进了糖尿病伤口细胞的增殖。在模拟DFU（mDFU）大鼠模型中，PBM（425、630、730和850 nm，以及联合光策略）促进了mDFU愈合。细胞增殖、再上皮化、血管生成、胶原蛋白合成及炎症反应呈阳性可能是其机制。联合策略效果最佳，可应用于临床。
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