口服镁补充剂预防性治疗偏头痛的循证综述
An evidence-based review of oral magnesium supplementation in the preventive treatment of migraine.
作者信息
Teigen Levi, Boes Christopher J
机构信息
Mayo Clinic College of Medicine, USA Mayo Clinic Department of Clinical Dietetics, USA
Mayo Clinic College of Medicine, USA Mayo Clinic Department of Neurology, USA.
出版信息
Cephalalgia. 2015 Sep;35(10):912-22. doi: 10.1177/0333102414564891. Epub 2014 Dec 22.
BACKGROUND
Migraine is an incompletely understood, debilitating disorder that lacks a universally effective treatment. Magnesium participates in a variety of biochemical processes related to migraine pathophysiology, and a deficiency could contribute to migraine development.
METHODS
A review of the literature from 1990 to the present on magnesium and migraine was conducted.
REVIEW
The authors identified 16 studies aimed at magnesium status assessment in migraine, and four intervention trials assessing the efficacy of oral magnesium supplementation, independent of other therapies, in the prevention of migraine.
CONCLUSION
The strength of evidence supporting oral magnesium supplementation is limited at this time. With such limited evidence, a more advantageous alternative to magnesium supplementation, in patients willing to make lifestyle changes, may be to focus on increasing dietary magnesium intake.
背景
偏头痛是一种尚未被完全理解的使人衰弱的疾病，缺乏一种普遍有效的治疗方法。镁参与了与偏头痛病理生理学相关的多种生化过程，缺乏镁可能导致偏头痛的发生。
方法
对1990年至今有关镁与偏头痛的文献进行了综述。
综述
作者确定了16项旨在评估偏头痛患者镁状态的研究，以及4项评估口服补充镁（独立于其他疗法）预防偏头痛疗效的干预试验。
结论
目前支持口服补充镁的证据力度有限。鉴于证据如此有限，对于愿意改变生活方式的患者，比补充镁更有利的替代方法可能是着重增加饮食中镁的摄入量。
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