白蒿精油对啮齿动物空肠收缩的松弛作用。
Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions.
作者信息
Aziz Mohammed, Karim Ahmed, El Ouariachi El Mokhtar, Bouyanzer Abdelhamid, Amrani Souliman, Mekhfi Hassane, Ziyyat Abderrahim, Melhaoui Ahmed, Bnouham Mohamed, Legssyer Abdelkhaleq
机构信息
Laboratoire de Physiologie et d'Ethnopharmacologie, Université Mohammed I, Faculté des Sciences, BP 717, 60000, Oujda, Morocco.
出版信息
Sci Pharm. 2012 Apr-Jun;80(2):457-67. doi: 10.3797/scipharm.1106-13. Epub 2012 Jan 12.
Artemisia herba-alba Asso. is a shrub commonly encountered in Morocco. It is used in traditional medicine for treating intestinal disorders. The essential oil extracted from the plant's aerial parts reversibly relaxed the spontaneous tonus of the rabbit jejunum in a reversible concentration dependent manner with an IC(50) value of 97.33 ± 2.59 ng/ml and reversed the tonic contraction of rat jejunum induced by 75 mM KCl and 10(-6) M carbachol with IC(50) values of 115.5 ± 3.05 and 119.4 ± 20.86 ng/ml, respectively. The pre-treatment of the latter isolated intestine with this essential oil produced a dose-dependent shift of the Ca(++) and CCh dose-response curve to the right, with suppression of the maximal effect, similar to the non-competitive antagonist effect on muscarinic receptors and calcium channel, respectively.
白蒿是摩洛哥常见的一种灌木。它在传统医学中用于治疗肠道疾病。从该植物地上部分提取的精油以可逆的浓度依赖性方式使兔空肠的自发张力可逆性松弛，IC(50)值为97.33±2.59 ng/ml，并使由75 mM氯化钾和10(-6) M卡巴胆碱诱导的大鼠空肠强直性收缩逆转，IC(50)值分别为115.5±3.05和119.4±20.86 ng/ml。用这种精油对后者的离体肠进行预处理，使Ca(++)和CCh剂量反应曲线呈剂量依赖性向右移动，并抑制最大效应，分别类似于对毒蕈碱受体和钙通道的非竞争性拮抗剂作用。
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