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皮肤移植后浆母细胞性淋巴瘤。

Post-transplant plasmablastic lymphoma of the skin.

机构信息

Department of Dermatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

出版信息

Australas J Dermatol. 2013 Nov;54(4):277-82. doi: 10.1111/j.1440-0960.2012.00939.x. Epub 2012 Aug 17.

Abstract

Plasmablastic lymphoma (PBL) is a recently described rare variant of diffuse large B-cell lymphoma characterised by its aggressive nature and plasmacytic differentiation. It most frequently arises in the oral cavity of human immunodeficiency virus (HIV)-infected patients. However extra-oral involvement is becoming increasingly recognised, particularly in HIV-negative patients. We report a case of PBL presenting as multiple violaceous nodules and plaques on the leg of a HIV-negative patient, 13-years post-renal transplant. To date, 20 cases of PBL presenting in the skin have been reported. We review and compare the clinico-pathological features of these cases.

摘要

浆母细胞淋巴瘤(PBL)是一种新近描述的弥漫性大 B 细胞淋巴瘤的罕见变异型,其特征为侵袭性和浆细胞分化。它最常发生在人类免疫缺陷病毒(HIV)感染患者的口腔中。然而,越来越多的人认识到其也会发生在口腔以外的部位,尤其是在 HIV 阴性患者中。我们报告了一例 HIV 阴性患者肾移植 13 年后,腿部出现多发性紫红色结节和斑块的 PBL 病例。迄今为止,已有 20 例 PBL 病例在皮肤中出现。我们对这些病例的临床病理特征进行了回顾和比较。

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