O'Neill Christina L, O'Doherty Michelle T, Wilson Sarah Ej, Rana Amer A, Hirst Claire E, Stitt Alan W, Medina Reinhold J
Stem Cell Res Ther. 2012 Aug 16;3(4):31. doi: 10.1186/scrt122.
Ischaemia-related diseases such as peripheral artery disease and coronary heart disease constitute a major issue in medicine as they affect millions of individuals each year and represent a considerable economic burden to healthcare systems. If the underlying ischaemia is not sufficiently resolved it can lead to tissue damage, with subsequent cell death. Treating such diseases remains difficult and several strategies have been used to stimulate the growth of blood vessels and promote regeneration of ischaemic tissues, such as the use of recombinant proteins and gene therapy. Although these approaches remain promising, they have limitations and results from clinical trials using these methods have had limited success. Recently, there has been growing interest in the therapeutic potential of using a cell-based approach to treat vasodegenerative disorders. In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases.
诸如外周动脉疾病和冠心病等缺血性疾病是医学领域的一个重大问题，因为它们每年影响数百万个体，给医疗保健系统带来相当大的经济负担。如果潜在的缺血情况得不到充分缓解，可能会导致组织损伤，继而引发细胞死亡。治疗这类疾病仍然困难重重，人们已经采用了多种策略来刺激血管生长并促进缺血组织的再生，比如使用重组蛋白和基因疗法。尽管这些方法仍然很有前景，但它们存在局限性，使用这些方法的临床试验结果成效有限。最近，利用基于细胞的方法治疗血管退行性疾病的治疗潜力越来越受到关注。在血管医学中，各种干细胞和成年祖细胞已被强调在缺血组织中具有血管修复作用。本综述将探讨几种干细胞和祖细胞的临床潜力，这些细胞可用于使功能丧失或受损的脉管系统再生，并恢复缺血组织的血流。特别是，我们将重点关注内皮祖细胞作为治疗缺血性疾病的一个令人兴奋的新选择的治疗潜力。
