Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan Province, People's Republic of China.
Inflammation. 2013 Feb;36(1):121-30. doi: 10.1007/s10753-012-9526-6.
Toll-like receptors (TLRs), the innate immunity components, have been demonstrated to participate in multiple autoimmune diseases. However, our knowledge of the roles of TLRs in myasthenia gravis (MG) is still scarce. In this study, we detected the mRNA expression of TLR1 to TLR10 in peripheral blood mononuclear cells (PBMCs) of MG patients and the healthy controls by quantitative real-time polymerase transcription chain reaction. Our data demonstrate that aberrant expressions of TLRs exist in the PBMCs of MG patients and of the total, expression level of TLR9 mRNA has significantly positive relation with the clinical severity of MG, which suggests that TLRs may be involved in the pathogenesis of MG.
Toll 样受体 (TLRs) 作为先天免疫成分，已被证实参与多种自身免疫性疾病。然而，我们对 TLRs 在重症肌无力 (MG) 中的作用知之甚少。在这项研究中，我们通过实时定量聚合酶转录链反应检测了 MG 患者和健康对照者外周血单个核细胞 (PBMCs) 中 TLR1 到 TLR10 的 mRNA 表达。我们的数据表明，MG 患者的 PBMCs 中存在 TLRs 的异常表达，并且总的来说，TLR9 mRNA 的表达水平与 MG 的临床严重程度呈显著正相关，这表明 TLRs 可能参与了 MG 的发病机制。
