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美沙酮剂量应急契约在临床应用中的困难。

Difficulties in a clinical application of methadone-dose contingency contracting.

作者信息

Nolimal D, Crowley T J

机构信息

Addiction Research and Treatment Service, University of Colorado Health Sciences Center, Denver.

出版信息

J Subst Abuse Treat. 1990;7(4):219-24. doi: 10.1016/0740-5472(90)90044-q.

Abstract

We review outcome of 14 methadone-maintenance patients who were offered a choice of administrative discharge or a methadone-dose contingency contract for continued drug abuse. In the three months before intervention, only 38% of urines were drug-free, while 55% were drug-free during the three-month intervention. Marked improvement occurred during the first month, while later the effect faded. Nine patients discontinued or reduced drug abuse, arriving at stable or fluctuating dose, and did not detoxify. Five others continued drug abuse, eventually reducing their methadone doses to zero. The procedure at least temporarily reduced drug abuse among the former group, but lack of uniformity in applying contingencies may have weakened the effect. Considering the spreading AIDS epidemic, we review the confusing literature on management of still-abusing methadone maintenance patients and suggest a protocol for their treatment.

摘要

我们回顾了14名接受美沙酮维持治疗的患者的结果,这些患者可选择被行政出院或签订美沙酮剂量应急合同以应对持续的药物滥用问题。在干预前的三个月里,只有38%的尿液检测未发现药物,而在为期三个月的干预期间,这一比例为55%。在第一个月出现了显著改善,但后来效果逐渐消退。9名患者停止或减少了药物滥用,达到了稳定或波动的剂量,且未进行戒毒。另外5名患者继续药物滥用,最终将美沙酮剂量减至零。该程序至少暂时减少了前一组患者的药物滥用,但在应用应急措施方面缺乏一致性可能削弱了效果。考虑到艾滋病疫情的蔓延,我们回顾了关于仍在滥用药物的美沙酮维持治疗患者管理的令人困惑的文献,并提出了他们的治疗方案。

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