Department of General Surgery, Faculty of Medicine, Dicle University, Diyarbakır,Turkey.
Med Princ Pract. 2015;24(2):153-8. doi: 10.1159/000369020. Epub 2014 Dec 10.
The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model.
Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined.
There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 ± 11.8 µg/mg) and the curcumin (63.8 ± 13.9 µg/mg) group compared to the control group (85.7 ± 22.1 µg/mg; p < 0.05).
These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation.
本研究旨在确定姜黄素对大鼠盲肠磨损模型中粘连形成的影响。
将 30 只 Wistar 大鼠随机分为三组；对照组给予生理盐水，姜黄素组在盲肠磨损后给予 10mg/kg 的姜黄素，而假手术组仅关闭腹壁，不磨损盲肠。第 15 天，使用标准化量表盲法评估粘连程度，并采集和检查组织病理学样本。
三组动物均无切口疝或伤口裂开。姜黄素组（中位数=1）和对照组（中位数=2；p<0.05）的粘连评分比较差异有统计学意义。姜黄素组（中位数=1）和假手术组（中位数=0）的炎症程度明显低于对照组（中位数=3；p<0.01 和 p<0.001）。与对照组（85.7±22.1µg/mg）相比，假手术组（48.3±11.8µg/mg）和姜黄素组（63.8±13.9µg/mg）的羟脯氨酸水平明显降低（p<0.05）。
这些数据表明，腹腔内给予姜黄素可有效预防腹膜粘连形成。
