LREN, Department of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois (CHUV), and University of Lausanne, Lausanne, Switzerland.
Neurobiol Aging. 2013 Mar;34(3):694-705. doi: 10.1016/j.neurobiolaging.2012.07.012. Epub 2012 Aug 14.
Alzheimer's disease (AD) disrupts functional connectivity in distributed cortical networks. We analyzed changes in the S-estimator, a measure of multivariate intraregional synchronization, in electroencephalogram (EEG) source space in 15 mild AD patients versus 15 age-matched controls to evaluate its potential as a marker of AD progression. All participants underwent 2 clinical evaluations and 2 EEG recording sessions on diagnosis and after a year. The main effect of AD was hyposynchronization in the medial temporal and frontal regions and relative hypersynchronization in posterior cingulate, precuneus, cuneus, and parietotemporal cortices. However, the S-estimator did not change over time in either group. This result motivated an analysis of rapidly progressing AD versus slow-progressing patients. Rapidly progressing AD patients showed a significant reduction in synchronization with time, manifest in left frontotemporal cortex. Thus, the evolution of source EEG synchronization over time is correlated with the rate of disease progression and should be considered as a cost-effective AD biomarker.
阿尔茨海默病（AD）会破坏分布式皮质网络的功能连接。我们分析了脑电图（EEG）源空间中 S 估计量（一种衡量区域间多变量同步的指标）在 15 名轻度 AD 患者与 15 名年龄匹配的对照组中的变化，以评估其作为 AD 进展标志物的潜力。所有参与者在诊断时和一年后进行了 2 次临床评估和 2 次 EEG 记录。AD 的主要影响是在中颞叶和额叶区域的去同步化，以及在后扣带回、楔前叶、楔叶和顶颞叶皮质的相对超同步化。然而，在两组中，S 估计量都没有随时间变化。这一结果促使我们对快速进展型 AD 与缓慢进展型患者进行了分析。快速进展型 AD 患者的同步性随时间显著降低，表现为左额颞叶皮质。因此，源 EEG 同步性随时间的演变与疾病进展的速度相关，应被视为一种具有成本效益的 AD 生物标志物。
