Papaliagkas Vasileios
Department of Biomedical Sciences, International Hellenic University, 57400 Thessaloniki, Greece.
Diagnostics (Basel). 2025 Aug 5;15(15):1965. doi: 10.3390/diagnostics15151965.
Alzheimer's disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline and functional impairment. Although advanced neuroimaging and cerebrospinal fluid biomarkers have improved early detection, their high costs, invasiveness, and limited accessibility restrict universal screening. Quantitative electroencephalography (qEEG) offers a non-invasive and cost-effective alternative for assessing neurophysiological changes associated with AD. This review critically evaluates current evidence on EEG biomarkers, including spectral, connectivity, and complexity measures, discussing their pathophysiological basis, diagnostic accuracy, and clinical utility in AD. Limitations and future perspectives, especially in developing standardized protocols and integrating machine learning techniques, are also addressed.
阿尔茨海默病是最常见的神经退行性疾病,会导致进行性认知衰退和功能障碍。尽管先进的神经影像学和脑脊液生物标志物改善了早期检测,但它们的高成本、侵入性以及有限的可及性限制了普遍筛查。定量脑电图(qEEG)为评估与阿尔茨海默病相关的神经生理变化提供了一种非侵入性且具有成本效益的替代方法。本综述批判性地评估了关于脑电图生物标志物的现有证据,包括频谱、连通性和复杂性测量,讨论了它们在阿尔茨海默病中的病理生理基础、诊断准确性和临床效用。还讨论了局限性和未来展望,特别是在制定标准化方案和整合机器学习技术方面。
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