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定量脑电图在阿尔茨海默病诊断中的作用。

The Role of Quantitative EEG in the Diagnosis of Alzheimer's Disease.

作者信息

Papaliagkas Vasileios

机构信息

Department of Biomedical Sciences, International Hellenic University, 57400 Thessaloniki, Greece.

出版信息

Diagnostics (Basel). 2025 Aug 5;15(15):1965. doi: 10.3390/diagnostics15151965.


DOI:10.3390/diagnostics15151965
PMID:40804929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12346855/
Abstract

Alzheimer's disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline and functional impairment. Although advanced neuroimaging and cerebrospinal fluid biomarkers have improved early detection, their high costs, invasiveness, and limited accessibility restrict universal screening. Quantitative electroencephalography (qEEG) offers a non-invasive and cost-effective alternative for assessing neurophysiological changes associated with AD. This review critically evaluates current evidence on EEG biomarkers, including spectral, connectivity, and complexity measures, discussing their pathophysiological basis, diagnostic accuracy, and clinical utility in AD. Limitations and future perspectives, especially in developing standardized protocols and integrating machine learning techniques, are also addressed.

摘要

阿尔茨海默病是最常见的神经退行性疾病,会导致进行性认知衰退和功能障碍。尽管先进的神经影像学和脑脊液生物标志物改善了早期检测,但它们的高成本、侵入性以及有限的可及性限制了普遍筛查。定量脑电图(qEEG)为评估与阿尔茨海默病相关的神经生理变化提供了一种非侵入性且具有成本效益的替代方法。本综述批判性地评估了关于脑电图生物标志物的现有证据,包括频谱、连通性和复杂性测量,讨论了它们在阿尔茨海默病中的病理生理基础、诊断准确性和临床效用。还讨论了局限性和未来展望,特别是在制定标准化方案和整合机器学习技术方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d57/12346855/5d93b8887364/diagnostics-15-01965-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d57/12346855/5d93b8887364/diagnostics-15-01965-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d57/12346855/5d93b8887364/diagnostics-15-01965-g001.jpg

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本文引用的文献

[1]
Revolutionizing Therapeutic Approaches Against Pathophysiology of Alzheimer's Disease: A Therapeutic Review.

Curr Aging Sci. 2025-7-31

[2]
The role of quantitative EEG biomarkers in Alzheimer's disease and mild cognitive impairment: applications and insights.

Front Aging Neurosci. 2025-4-23

[3]
EEG-based neurodegenerative disease diagnosis: comparative analysis of conventional methods and deep learning models.

Sci Rep. 2025-5-7

[4]
Blood-Based β-Amyloid and Phosphorylated Tau (p-Tau) Biomarkers in Alzheimer's Disease: A Systematic Review of Their Diagnostic Potential.

Cureus. 2025-3-1

[5]
Unlocking the potential of EEG in Alzheimer's disease research: Current status and pathways to precision detection.

Brain Res Bull. 2025-4

[6]
Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease.

Int J Mol Sci. 2025-1-3

[7]
Differentiating neurodegenerative diseases based on EEG complexity.

Sci Rep. 2024-10-17

[8]
Assessing the Potential of EEG in Early Detection of Alzheimer's Disease: A Systematic Comprehensive Review (2000-2023).

J Alzheimers Dis Rep. 2024-8-20

[9]
Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies.

Signal Transduct Target Ther. 2024-8-23

[10]
Deep Learning for Alzheimer's Disease Prediction: A Comprehensive Review.

Diagnostics (Basel). 2024-6-17

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