含 2'-二十二酰基紫杉醇的载药脂质纳米粒治疗转移性乳腺癌。
2'-Behenoyl-paclitaxel conjugate containing lipid nanoparticles for the treatment of metastatic breast cancer.
机构信息
Center for Nanotechnology in Drug Delivery, Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Cancer Lett. 2013 Jul 1;334(2):253-62. doi: 10.1016/j.canlet.2012.08.009. Epub 2012 Aug 16.
Abstract
The aim of these studies was to develop a novel 2'-behenoyl-paclitaxel (C22-PX) conjugate nanoparticle (NP) formulation for the treatment of metastatic breast cancer. A lipophilic paclitaxel derivative C22-PX was synthesized and incorporated into lipid-based NPs. Free C22-PX and its NP formulation were evaluated in a series of in vitro and in vivo studies. The results demonstrated that C22-PX NPs were much better tolerated and had significantly higher plasma and tumor AUCs compared to Taxol at the maximum tolerated dose (MTD) in a subcutaneous 4T1 mouse mammary carcinoma model. These benefits resulted in significantly improved antitumor efficacy with the NP-based formulation.
摘要
这些研究的目的是开发一种新型的 2'-二十二酰基紫杉醇（C22-PX）缀合物纳米颗粒（NP）制剂，用于治疗转移性乳腺癌。合成了一种亲脂性紫杉醇衍生物 C22-PX 并将其纳入脂质 NPs 中。在一系列体外和体内研究中评估了游离 C22-PX 及其 NP 制剂。结果表明，在皮下 4T1 小鼠乳腺癌模型中，与 Taxol 相比，在最大耐受剂量（MTD）下，C22-PX NPs 的耐受性更好，且血浆和肿瘤 AUC 显著更高。这些益处导致基于 NP 的制剂的抗肿瘤疗效显著提高。
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Int J Nanomedicine. 2011;6:2545-56. doi: 10.2147/IJN.S24954. Epub 2011 Oct 21.
2
Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel -polymer micelles to overcome multi-drug resistance.叶酸介导的靶向作用与维拉帕米介导的 P-糖蛋白抑制联合紫杉醇聚合物胶束克服多药耐药性。
Biomaterials. 2011 Dec;32(35):9444-56. doi: 10.1016/j.biomaterials.2011.08.041. Epub 2011 Sep 7.
3
PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy.紫杉醇的 PEG 脂质体化改善了其体内分布和抗肿瘤疗效。
Int J Pharm. 2011 Jun 30;412(1-2):132-41. doi: 10.1016/j.ijpharm.2011.04.008. Epub 2011 Apr 12.
4
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ACS Nano. 2011 Jan 25;5(1):209-16. doi: 10.1021/nn102357y. Epub 2010 Dec 15.
5
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Ann Oncol. 2011 Apr;22(4):787-793. doi: 10.1093/annonc/mdq438. Epub 2010 Sep 20.
6
Functional study of the novel multidrug resistance gene HA117 and its comparison to multidrug resistance gene 1.新型多药耐药基因 HA117 的功能研究及其与多药耐药基因 1 的比较。
J Exp Clin Cancer Res. 2010 Jul 19;29(1):98. doi: 10.1186/1756-9966-29-98.
7
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8
Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia.研制伊达比星和多柔比星固体脂质纳米粒以克服白血病中的 Pgp 介导的多药耐药性。
J Biomed Nanotechnol. 2009 Apr;5(2):151-61. doi: 10.1166/jbn.2009.1021.
9
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10
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Cancer Res. 2009 May 1;69(9):3918-26. doi: 10.1158/0008-5472.CAN-08-2747. Epub 2009 Apr 21.
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