Faculty of Periodontics, Capital Medical University School of Stomatology, Tian Tan Xi Li No 4, Beijing 100050, China.
Int J Biochem Cell Biol. 2012 Nov;44(11):2044-50. doi: 10.1016/j.biocel.2012.08.003. Epub 2012 Aug 9.
Significant progress has been made in stem cell biology, regenerative medicine, and stem cell-based tissue engineering. Such scientific strides highlight the potential of replacing or repairing damaged tissues in congenital abnormalities, diseases, or injuries, as well as constructing functional tissue or organs in vivo. Since mesenchymal stem cells (MSCs) are capable of differentiating into bone-forming cells, they constitute an appropriate cell source to repair damaged bone tissues. In addition, the immunoregulatory property of MSCs provides a foundation for their use in treating a variety of autoimmune diseases. However, the interaction between MSCs and immune cells in cell-based tissue regeneration is largely unknown. In this review, we will discuss the current understanding of MSC-based tissue regeneration, emphasizing the role of the immune microenvironment in bone regeneration.
在干细胞生物学、再生医学和基于干细胞的组织工程学方面取得了重大进展。这些科学进展突出了在先天性异常、疾病或损伤中替代或修复受损组织以及在体内构建功能性组织或器官的潜力。由于间充质干细胞 (MSCs) 能够分化为成骨细胞，因此它们构成了修复受损骨组织的合适细胞来源。此外，MSCs 的免疫调节特性为其在治疗各种自身免疫性疾病中的应用奠定了基础。然而，基于细胞的组织再生中 MSC 与免疫细胞之间的相互作用在很大程度上尚不清楚。在这篇综述中，我们将讨论基于 MSC 的组织再生的现有认识，强调免疫微环境在骨再生中的作用。
