Department of Public Health, Saitama Medical University Faculty of Medicine, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
Mod Rheumatol. 2013 Jul;23(4):759-64. doi: 10.1007/s10165-012-0733-7. Epub 2012 Aug 19.
The aim of this study was to describe age, gender distribution, and age at onset of systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM), and systemic sclerosis (SSc) in Japan.
We used epidemiological information on 21,405, 6,327, and 10,058 patients with SLE, PM/DM, and SSc, respectively, in a Japanese nationwide registration database of patients with intractable diseases.
All three diseases occur predominantly in women, with the female-to-male ratio being 8.2:1, 2.6:1, and 7.7:1 for SLE, PM/DM, and SSc, respectively. The most susceptible age for SLE is 15-44 and 20-39 years for males and females, respectively. For PM/DM it is 45-64 and 40-64 years and for SSc, 50-69 and 40-59 for men and women, respectively.
The basic descriptive epidemiological characteristics of SLE, PM/DM, and SSc in Japan, such as gender distribution, present age, and age at onset, were surveyed nationwide for fiscal 2007. It was found that these characteristics were similar to those in Western populations. Our finding provides new information on the natural history of disease development.
本研究旨在描述日本系统性红斑狼疮（SLE）、多发性肌炎/皮肌炎（PM/DM）和系统性硬皮病（SSc）的发病年龄、性别分布和发病年龄。
我们使用了日本难治性疾病患者全国登记数据库中 21405 例 SLE、6327 例 PM/DM 和 10058 例 SSc 患者的流行病学信息。
这三种疾病主要发生在女性中，SLE、PM/DM 和 SSc 的男女比例分别为 8.2:1、2.6:1 和 7.7:1。SLE 最易感年龄为 15-44 岁，男性和女性分别为 20-39 岁。PM/DM 为 45-64 岁和 40-64 岁，SSc 为 50-69 岁和 40-59 岁，分别为男性和女性。
本研究对日本 2007 年 SLE、PM/DM 和 SSc 的基本描述性流行病学特征，如性别分布、现患年龄和发病年龄进行了全国性调查。结果表明，这些特征与西方人群相似。我们的发现为疾病发展的自然史提供了新的信息。
