在正常衰老或轻度认知障碍中，高等教育与与读写能力或智力相关的大脑区域的皮质厚度增加无关。
Higher education is not associated with greater cortical thickness in brain areas related to literacy or intelligence in normal aging or mild cognitive impairment.
机构信息
Department of Neurology, VA San Diego Medical Center, San Diego, CA, USA.
出版信息
J Clin Exp Neuropsychol. 2012;34(9):925-35. doi: 10.1080/13803395.2012.702733. Epub 2012 Aug 21.
Abstract
Education may reduce risk of dementia through passive reserve, by increasing neural substrate. We tested the hypotheses that education is associated with thicker cortex and reduced rates of atrophy in brain regions related to literacy and intellectual ability. Healthy older adults and those with mild cognitive impairment were categorized into high (≥18 years) and low (≤13 years) education groups. Higher education was associated with thinner cortices in several areas, but one-year atrophy rates in these areas did not differ by education group. These results do not support a passive reserve model in which early-life education protects against dementia by increasing cortical thickness. Connectivity and synaptic efficiency or other lifestyle factors may more directly reflect cognitive reserve.
摘要
教育可能通过增加神经基质来减少痴呆的风险，即被动储备。我们测试了以下假设：教育与与读写和智力能力相关的脑区的皮层增厚和萎缩率降低有关。健康的老年人和轻度认知障碍者被分为高（≥ 18 年）和低（≤ 13 年）教育组。较高的教育水平与几个区域的皮质变薄有关，但这些区域的一年萎缩率在教育组之间没有差异。这些结果不支持被动储备模型，即早期教育通过增加皮质厚度来预防痴呆。连通性和突触效率或其他生活方式因素可能更直接地反映认知储备。
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