Department of Psychiatry and Neuropsychology, European Graduate School for Neuroscience, SEARCH, Maastricht University Medical Centre, MD Maastricht, the Netherlands.
Acta Psychiatr Scand. 2013 Apr;127(4):318-27. doi: 10.1111/j.1600-0447.2012.01924.x. Epub 2012 Aug 20.
The daily life, affective phenotypes of momentary negative affect (NA), positive affect (PA) variability and NA variability are associated with future depressive symptomatology. This study investigates the extent to which genetic and environmental factors contribute to the inter-individual differences in these daily life, affective phenotypes.
Two hundred and seventy-nine female twins from the Flemish (Belgium) general population participated in an experience sampling study measuring affect in daily life. Structural equation modelling was used to fit univariate and bivariate models.
Genetic factors explained, respectively, 18%, 18% and 35% of the inter-individual differences in momentary NA, PA variability and NA variability. Non-shared environmental factors were found to explain the remaining inter-individual variation. In addition, 41% of the association between positive and NA variability was attributed to shared genetic factors.
Results of this study show that daily life patterns of affective expression are subject to substantial environmental influence. Prospective assessments of the effect of interventions on these expressions may therefore represent a powerful tool to prevent transition from subclinical depressive symptomatology to a clinical outcome or to reduce symptomatology in those with clinical depression.
日常生活、瞬间负性情绪(NA)的情感表现型、正性情绪(PA)变异性和 NA 变异性与未来的抑郁症状有关。本研究旨在探讨遗传和环境因素在多大程度上导致了这些日常生活、情感表现型的个体差异。
来自佛兰芒(比利时)普通人群的 279 名女性双胞胎参加了一项经验抽样研究,该研究在日常生活中测量了情绪。采用结构方程模型对单变量和双变量模型进行拟合。
遗传因素分别解释了瞬间 NA、PA 变异性和 NA 变异性的个体差异的 18%、18%和 35%。非共享环境因素解释了剩余的个体间变异。此外,正性和 NA 变异性之间的 41%的相关性归因于共享的遗传因素。
本研究的结果表明,情感表达的日常生活模式受到环境的显著影响。因此,对这些表达进行干预效果的前瞻性评估可能代表了预防亚临床抑郁症状向临床结局转变或减少临床抑郁患者症状的有力工具。