Serum overexpression of microRNA-10b in patients with bone metastatic primary breast cancer.

OBJECTIVE

Bone metastasis is a major complication of advanced breast cancer. The present prospective case-control study investigated the involvement of microRNA (miR)-10b in the development of bone metastasis arising from primary breast carcinoma.

METHODS

Serum miR-10b concentrations were determined by quantitative real-time reverse transcription-polymerase chain reaction in 122 patients with breast cancer, with or without bone metastases, and 59 age-matched healthy control subjects.

RESULTS

Serum miR-10b concentrations were significantly higher in patients with bone metastases than in patients without bone metastases or control subjects. Serum miR-10b had an area under the receiver operating characteristic curve for the presence of bone metastases of 0.769, with 64.8% sensitivity and 69.5% specificity.

CONCLUSION

These results suggest that serum miR-10b may be a useful biomarker for the identification of bone metastatic breast cancer.