Krutchkoff D J, Chen J K, Eisenberg E, Katz R V
Department of Oral Diagnosis/Pathology, University of Connecticut, Farmington.
Oral Surg Oral Med Oral Pathol. 1990 Aug;70(2):192-8. doi: 10.1016/0030-4220(90)90118-c.
A survey of the University of Connecticut Oral Pathology Biopsy Service was undertaken to analyze cases of oral cancer accessioned during the 12-year period, 1975 through 1986 inclusive. Of 33,429 total specimens accessioned, there were 546 malignant oral neoplasms diagnosed and reported. Sixty-five (11.5%) originated from out of state. Invasive intraoral squamous cell carcinoma was the predominant tumor (69.7% of total), whereas lip cancer constituted only 2.8% of all malignancies. Minor salivary gland adenocarcinomas accounted for 11% of total malignancies whereas verrucous carcinoma, carcinoma in situ, and miscellaneous other forms of oral cancer accounted for the remainder (4.6%, 5.3%, and 6.6%, respectively). Cases of invasive squamous cell carcinoma were further analyzed by year, sex distribution, location subsite, age at diagnosis, and histologic grade. With the exception of histologic grading, we found that the characterization of cases of squamous cell carcinoma within the biopsy service tended to parallel results from a separate but related statewide analysis of both oral cancer and intraoral squamous cell carcinoma from Connecticut over a much longer time span. We concluded that the picture of oral cancer as characterized by cases within the University of Connecticut Oral Pathology Biopsy Service is generally reflective of the disease on a statewide level.
对康涅狄格大学口腔病理学活检服务进行了一项调查，以分析1975年至1986年（含）这12年期间登记的口腔癌病例。在总共登记的33429份标本中，有546例被诊断并报告为口腔恶性肿瘤。其中65例（11.5%）来自外州。浸润性口腔鳞状细胞癌是主要肿瘤类型（占总数的69.7%），而唇癌仅占所有恶性肿瘤的2.8%。小唾液腺癌占所有恶性肿瘤的11%，而疣状癌、原位癌和其他各种形式的口腔癌占其余部分（分别为4.6%、5.3%和6.6%）。对浸润性鳞状细胞癌病例进一步按年份、性别分布、部位亚部位、诊断时年龄和组织学分级进行分析。除组织学分级外，我们发现活检服务中鳞状细胞癌病例的特征往往与在更长时间段内对康涅狄格州口腔癌和口腔内鳞状细胞癌进行的一项单独但相关的全州分析结果相似。我们得出结论，康涅狄格大学口腔病理学活检服务中的病例所呈现的口腔癌情况总体上反映了该疾病在全州范围内的情况。
