Cancer Surveillance Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Cancer. 2012 Sep 1;118(17):4220-7. doi: 10.1002/cncr.27390. Epub 2012 Jan 3.
Primary tumors of the spinal cord, spinal meninges, and cauda equina are relatively rare, and a paucity of population-based data exist on tumors in these sites. This study intends to augment the current literature by examining incidence of these tumors on a national level.
Data from central cancer registries in the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results (SEER) programs for 2004-2007 (covering 99.2% of US population) and 1999-2007 (covering 89.4% of US population) were analyzed. Analyses for diagnosis years 2004-2007 included cases of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumors. Descriptive statistics including estimated age-adjusted incidence rates standardized to the 2000 US standard population were conducted for both malignant and nonmalignant primary spinal tumors from cases diagnosed during 2004-2007 as well as trend analyses on malignant cases of primary spinal tumors (n = 5103) for cases diagnosed during 1999-2007 using SEER Stat 6.6.2 software.
There were 2576 cases of malignant primary spinal tumors and 9136 cases of nonmalignant primary spinal tumors in 2004-2007. The incidence of malignant and nonmalignant primary spinal tumors combined differed by age, sex, race, and ethnicity. Results of trend analyses indicated that malignant primary spinal tumors have been stable throughout the 1999-2007 period.
This large population-based study adds new insights into the descriptive epidemiology of primary spinal cord, spinal meninges, and cauda equina tumors by providing in-depth analyses of the incidence of these tumors on a national level.
脊髓、脊髓膜和马尾原发性肿瘤较为少见，目前针对这些部位肿瘤的人群数据也较为缺乏。本研究旨在通过研究全国范围内的肿瘤发病率，进一步丰富现有文献。
对美国国家癌症登记计划（NPCR）和监测、流行病学和最终结果（SEER）计划中心癌症登记处的数据进行了分析，时间为 2004-2007 年（覆盖美国 99.2%的人口）和 1999-2007 年（覆盖美国 89.4%的人口）。2004-2007 年诊断年的分析包括恶性和非恶性原发性脊髓、脊髓膜和马尾肿瘤的病例。对诊断于 2004-2007 年的恶性和非恶性原发性脊髓肿瘤病例进行了描述性统计，包括根据 2000 年美国标准人口标准化的估计年龄调整发病率。使用 SEER Stat 6.6.2 软件对诊断于 1999-2007 年的 5103 例恶性原发性脊髓肿瘤病例进行了趋势分析。
2004-2007 年，共有 2576 例恶性原发性脊髓肿瘤和 9136 例非恶性原发性脊髓肿瘤。恶性和非恶性原发性脊髓肿瘤的发病率因年龄、性别、种族和族裔而异。趋势分析结果表明，恶性原发性脊髓肿瘤在 1999-2007 年期间一直保持稳定。
本大规模人群研究通过对全国范围内这些肿瘤的发病率进行深入分析，为原发性脊髓、脊髓膜和马尾肿瘤的描述性流行病学提供了新的见解。
