School of Mechatronics, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Korea.
IEEE Trans Neural Syst Rehabil Eng. 2013 Jul;21(4):544-53. doi: 10.1109/TNSRE.2012.2210560. Epub 2012 Aug 13.
This paper describes a largely deformable surface type neural electrode array based on polydimethylsiloxane (PDMS) for cortical use. Noncracked and reliable metal patterns were fabricated successfully on PDMS substrate by employing an intermediate parylene layer. The mechanical and electrical stability of the fabricated electrode arrays was demonstrated by repeatable bending test using a custom-designed bending test module. Also the adhesion of the electrode structure consisting of PDMS, parylene and metal layers was proven by ASTM tape test. The electrode impedance was measured in phosphate buffered saline (PBS) solution at 37 (°) C over three months and analyzed using equivalent circuit models. Based on these results, it is concluded that the suggested electrode array provides a largely deformable structure with mechanical integrity and electrical stability, which can withstand mechanical stresses when inserted through a small trephination hole in the skull and expanded in the small room between the cortex and the skull without damage to the electrode array.
本文描述了一种基于聚二甲基硅氧烷(PDMS)的、主要用于皮质的可大幅变形表面型神经电极阵列。通过采用中间的聚对二甲苯层,成功地在 PDMS 基底上制造出无裂缝且可靠的金属图案。通过使用定制设计的弯曲测试模块进行可重复的弯曲测试,证明了所制造的电极阵列的机械和电气稳定性。此外,通过 ASTM 胶带测试证明了由 PDMS、聚对二甲苯和金属层组成的电极结构的附着力。在 37°C(°)的磷酸盐缓冲盐溶液(PBS)中测量了电极阻抗,并使用等效电路模型进行了分析。基于这些结果,可以得出结论,所提出的电极阵列提供了一种具有机械完整性和电气稳定性的可大幅变形结构,当通过颅骨上的小颅骨钻孔插入并在皮质和颅骨之间的小空间中扩展时,它可以承受机械应力,而不会损坏电极阵列。