一种 PDMS-Parylene 混合硬膜下多电极阵列。
A hybrid PDMS-Parylene subdural multi-electrode array.
机构信息
School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Biomed Microdevices. 2013 Jun;15(3):437-43. doi: 10.1007/s10544-013-9743-2.
Abstract
In this paper, we report on a cost effective and simple method for fabricating a flexible multi-electrode array for subdural neural recording. The electrode was fabricated using a PDMS-Parylene bilayer to combine the major advantages of both materials. Mechanical and electrical characterizations were performed to confirm functionality of a 16-site electrode array under various flexed/bent conditions. The electrode array was helically wound around a 3 mm diameter cylindrical tube and laid over a 2 cm diameter sphere while maintaining its recording capability. Experimental results showed impedance values between 300 kΩ and 600 kΩ at 1 kHz for 90 μm diameter gold recording sites. Acoustically evoked neural activity was successfully recorded from rat auditory cortex, confirming in vivo functionality.
摘要
本文报道了一种经济实用且简单的方法，用于制造用于硬脑膜下神经记录的柔性多电极阵列。该电极采用 PDMS-聚对二甲苯双层结构制造，结合了两种材料的主要优势。进行了机械和电气特性评估，以确认在各种弯曲/弯曲条件下 16 位电极阵列的功能。该电极阵列被螺旋缠绕在 3 毫米直径的圆柱形管上，并铺设在 2 厘米直径的球体上，同时保持其记录能力。实验结果表明，90μm 直径金记录电极的阻抗值在 1 kHz 时为 300 kΩ 至 600 kΩ。成功地从大鼠听觉皮层记录到声诱发的神经活动，证实了体内功能。
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