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Carbapenem resistance in Enterobacteriaceae: here is the storm!肠杆菌科的碳青霉烯类耐药性：风暴将至！
Trends Mol Med. 2012 May;18(5):263-72. doi: 10.1016/j.molmed.2012.03.003. Epub 2012 Apr 3.
2
Class A carbapenemase FPH-1 from Francisella philomiragia.弗氏柠檬酸杆菌中的 A 类碳青霉烯酶 FPH-1。
Antimicrob Agents Chemother. 2012 Jun;56(6):2852-7. doi: 10.1128/AAC.00223-12. Epub 2012 Mar 26.
3
The class A β-lactamase FTU-1 is native to Francisella tularensis.A 类β-内酰胺酶 FTU-1 是土拉弗朗西斯菌的天然产物。
Antimicrob Agents Chemother. 2012 Feb;56(2):666-71. doi: 10.1128/AAC.05305-11. Epub 2011 Nov 14.
4
Elucidating the role of Trp105 in the KPC-2 β-lactamase.阐明 Trp105 在 KPC-2 β-内酰胺酶中的作用。
Protein Sci. 2010 Sep;19(9):1714-27. doi: 10.1002/pro.454.
5
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.KPC-2 酶中 237 位残基对底物的选择性和抑制剂识别的新作用。
Antimicrob Agents Chemother. 2010 Jul;54(7):2867-77. doi: 10.1128/AAC.00197-10. Epub 2010 Apr 26.
6
Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.KPC-2 型β-内酰胺酶的抑制剂耐药性，这种 A 类β-内酰胺酶的卓越特性。
Antimicrob Agents Chemother. 2010 Feb;54(2):890-7. doi: 10.1128/AAC.00693-09. Epub 2009 Dec 14.
7
Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.来自法国巴黎塞纳河的荧光假单胞菌分离株的新型 Ambler 类 A 碳青霉烯水解β-内酰胺酶。
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8
Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases.β-内酰胺酶GES家族对碳青霉烯类抗生素产生催化活性的机制基础。
J Biol Chem. 2009 Oct 23;284(43):29509-13. doi: 10.1074/jbc.M109.011262. Epub 2009 Aug 5.
9
The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.产肺炎克雷伯菌碳青霉烯酶细菌的真正威胁。
Lancet Infect Dis. 2009 Apr;9(4):228-36. doi: 10.1016/S1473-3099(09)70054-4.
10
Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4.新型KPC变体KPC-5及其进化变体KPC-2和KPC-4的表型和酶学比较分析。
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A 类碳青霉烯酶 KPC-6 的耐药性和底物谱。

Antibiotic resistance and substrate profiles of the class A carbapenemase KPC-6.

机构信息

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.

出版信息

Antimicrob Agents Chemother. 2012 Nov;56(11):6006-8. doi: 10.1128/AAC.01338-12. Epub 2012 Aug 20.

DOI:10.1128/AAC.01338-12
PMID:22908150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486543/
Abstract

The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(-1) s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater extent, ranging from 10(3) M(-1) s(-1) for the cephamycin cefoxitin and the extended-spectrum cephalosporin ceftazidime to 10(5) to 10(6) M(-1) s(-1) for the narrow-spectrum and some of the extended-spectrum cephalosporins.

摘要

A 类碳青霉烯酶 KPC-6 可导致对多种β-内酰胺类抗生素产生耐药性。该酶对青霉素类、单环β-内酰胺类氨曲南和碳青霉烯类的水解速度相似，酶动力学常数（Kcat）在 10(5) 到 10(6) M(-1) s(-1) 之间。KPC-6 对头孢菌素类的催化效率差异较大，头孢噻肟的 Kcat 值为 10(3) M(-1) s(-1)，头孢西丁为头孢菌素类的碳青霉烯类，而头孢他啶和头孢吡肟的 Kcat 值为 10(5) 到 10(6) M(-1) s(-1)。