Institute for Robotics and Cognitive Systems, University of Lübeck, Germany.
Int J Med Robot. 2012 Sep;8(3):327-36. doi: 10.1002/rcs.1425. Epub 2012 Mar 26.
With its high spatial and temporal resolution, optical coherence tomography (OCT) is an ideal modality for intra-operative imaging. One possible application is to detect tumour invaded tissue in neurosurgery, e.g. during complete resection of glioblastoma. Ideally, the whole resection cavity is scanned. However, OCT is limited to a small field of view (FOV) and scanning perpendicular to the tissue surface.
We present a new method to use OCT for scanning of the resection cavity during neurosurgical resection of brain tumours. The main challenges are creating a map of the cavity, scanning perpendicular to the surface and merging the three-dimensional (3D) data for intra-operative visualization and detection of residual tumour cells.
Our results indicate that the proposed method enables creating high-resolution maps of the resection cavity. An overlay of these maps with the microscope images provides the surgeon with important information on the location of residual tumour tissue underneath the surface.
We demonstrated that it is possible to automatically acquire an OCT image of the complete resection cavity. Overlaying microscopy images with depth information from OCT could lead to improved detection of residual tumour cells.
光学相干断层扫描（OCT）具有较高的空间和时间分辨率，是术中成像的理想方式。一种可能的应用是在神经外科中检测肿瘤侵袭组织，例如在完全切除脑胶质瘤时。理想情况下，整个切除腔都要进行扫描。然而，OCT 的视野（FOV）较小，且只能垂直于组织表面进行扫描。
我们提出了一种新的方法，用于在神经外科切除脑肿瘤期间使用 OCT 对切除腔进行扫描。主要挑战是创建腔的图谱、垂直于表面进行扫描，并合并三维（3D）数据，以便在术中可视化和检测残留的肿瘤细胞。
我们的结果表明，所提出的方法能够创建切除腔的高分辨率图谱。这些图谱与显微镜图像的叠加为外科医生提供了有关表面下残留肿瘤组织位置的重要信息。
我们证明了自动获取完整切除腔的 OCT 图像是可能的。将显微镜图像与来自 OCT 的深度信息叠加可能会提高对残留肿瘤细胞的检测能力。
