Abiaka Clifford, Machado Lovina
Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman;
Sultan Qaboos Univ Med J. 2012 Aug;12(3):300-5. doi: 10.12816/0003143. Epub 2012 Jul 15.
This study assessed the role of oxidative stress in parturition in Omani mothers following growing reports that late preterm neonates were at greater risk than term neonates of perinatal death.
Venous blood samples were collected during labour, and cord (neonatal) blood samples were taken after childbirth in late preterm and term from women at Sultan Qaboos University Hospital, Oman. Plasma nitric oxide (NO) concentrations, erythrocyte catalase (CAT). Erythrocyte glutathione peroxidase (GPx) activities were measured using spectrophotometric methods.
When compared with term mothers, late preterm mothers had markedly higher NO concentrations (μmol/L) 17.1 ± 3.3 versus 11.0 ± 5.5 (P <0.0001), and lower GPx values (U/g Hb) 94.1 ± 12.9 versus 110.4 ± 12.3 (P <0.0001). Late preterm mothers were significantly younger (P = 0.027) than term mothers and had neonates that weighed significantly less (P <0.0001) than term neonates. GPx activity was significantly reduced (P = 0.001) in late preterm neonates as compared to term neonates. CAT showed no change in activity in any comparison.
Distinctly higher values of NO and lower GPx activity were found in late preterm mothers relative to term mothers; also, lower GPx in late preterm neonates relative to term neonates suggested a pro-oxidant-antioxidant imbalance due to the greater oxidative burden in late preterm parturition.
越来越多的报告指出晚期早产儿围产期死亡风险高于足月儿，本研究旨在评估氧化应激在阿曼母亲分娩过程中的作用。
在阿曼苏丹卡布斯大学医院，收集晚期早产儿和足月儿母亲分娩时的静脉血样本以及产后的脐带（新生儿）血样本。采用分光光度法测量血浆一氧化氮（NO）浓度、红细胞过氧化氢酶（CAT）和红细胞谷胱甘肽过氧化物酶（GPx）活性。
与足月儿母亲相比，晚期早产儿母亲的NO浓度显著更高（μmol/L），分别为17.1±3.3和11.0±5.5（P<0.0001），而GPx值更低（U/g Hb），分别为94.1±12.9和110.4±12.3（P<0.0001）。晚期早产儿母亲比足月儿母亲明显更年轻（P = 0.027），其新生儿体重也明显低于足月儿（P<0.0001）。与足月儿相比，晚期早产儿的GPx活性显著降低（P = 0.001）。在任何比较中，CAT活性均无变化。
与足月儿母亲相比，晚期早产儿母亲的NO值明显更高，GPx活性更低；此外，与足月儿相比，晚期早产儿的GPx更低，这表明由于晚期早产分娩时氧化负担更大，导致了促氧化剂 - 抗氧化剂失衡。
