铝佐剂吸附重组蓖麻毒素疫苗的1B期临床试验
Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine.
作者信息
Vitetta Ellen S, Smallshaw Joan E, Schindler John
机构信息
Cancer Immunobiology Center, University of Texas Southwestern Medical School, Dallas, USA.
出版信息
Clin Vaccine Immunol. 2012 Oct;19(10):1697-9. doi: 10.1128/CVI.00381-12. Epub 2012 Aug 22.
Abstract
There is no FDA-approved vaccine for the potent plant toxin ricin. We have developed a recombinant ricin vaccine, RiVax. Without adjuvant it is safe and immunogenic in mice, rabbits, and humans. Based on our studies in mice, we now report the results of a small clinical trial with Alhydrogel-adsorbed RiVax.
摘要
目前尚无美国食品药品监督管理局（FDA）批准的针对强效植物毒素蓖麻毒素的疫苗。我们研发了一种重组蓖麻毒素疫苗RiVax。在无佐剂的情况下，它在小鼠、兔子和人类中均安全且具有免疫原性。基于我们在小鼠身上的研究，我们现在报告一项关于氢氧化铝吸附型RiVax的小型临床试验结果。
相似文献
1
Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine.铝佐剂吸附重组蓖麻毒素疫苗的1B期临床试验
Clin Vaccine Immunol. 2012 Oct;19(10):1697-9. doi: 10.1128/CVI.00381-12. Epub 2012 Aug 22.
2
A pilot clinical trial of a recombinant ricin vaccine in normal humans.重组蓖麻毒素疫苗在正常人体中的初步临床试验。
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2268-73. doi: 10.1073/pnas.0510893103. Epub 2006 Feb 3.
3
RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol.RiVax是一种重组蓖麻毒素亚单位疫苗，可保护小鼠免受经口或气溶胶途径给予的蓖麻毒素侵害。
Vaccine. 2007 Oct 16;25(42):7459-69. doi: 10.1016/j.vaccine.2007.08.018. Epub 2007 Aug 30.
4
Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice.两种主要候选蓖麻毒素A亚基疫苗在小鼠体内的比较疗效
Clin Vaccine Immunol. 2013 Jun;20(6):789-94. doi: 10.1128/CVI.00098-13. Epub 2013 Mar 20.
5
Preclinical toxicity and efficacy testing of RiVax, a recombinant protein vaccine against ricin.抗蓖麻毒素重组蛋白疫苗RiVax的临床前毒性和疗效测试。
Vaccine. 2005 Sep 15;23(39):4775-84. doi: 10.1016/j.vaccine.2005.04.037.
6
Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine.热稳定冻干单价疫苗诱导蓖麻毒素的持久免疫力。
mSphere. 2021 Dec 22;6(6):e0075021. doi: 10.1128/mSphere.00750-21. Epub 2021 Nov 3.
7
Safety and immunogenicity of ricin vaccine, RVEc™, in a Phase 1 clinical trial.蓖麻毒素疫苗RVEc™在1期临床试验中的安全性和免疫原性。
Vaccine. 2015 Dec 16;33(51):7299-7306. doi: 10.1016/j.vaccine.2015.10.094. Epub 2015 Nov 3.
8
Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication.皮内给药 RiVax 可保护小鼠免受粘膜和全身蓖麻毒素中毒。
Vaccine. 2010 Jul 19;28(32):5315-22. doi: 10.1016/j.vaccine.2010.05.045. Epub 2010 Jun 1.
9
Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen.单点突变对重组蓖麻毒素 A 链亚单位疫苗抗原稳定性和免疫原性的影响。
Hum Vaccin Immunother. 2013 Apr;9(4):744-52. doi: 10.4161/hv.22998. Epub 2013 Apr 1.
10
Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine.冻干粉化蓖麻毒素毒素亚单位疫苗的热稳定性和抗原表位完整性。
Vaccine. 2018 Sep 25;36(40):5967-5976. doi: 10.1016/j.vaccine.2018.08.059. Epub 2018 Aug 29.
引用本文的文献
1
Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies.针对主要生物战剂的有效医学应对措施的研发：抗体的重要性
Microorganisms. 2024 Dec 18;12(12):2622. doi: 10.3390/microorganisms12122622.
2
Toxicity and Efficacy Evaluation of Soluble Recombinant Ricin Vaccine.可溶性重组蓖麻毒素疫苗的毒性与疗效评估
Vaccines (Basel). 2024 Sep 29;12(10):1116. doi: 10.3390/vaccines12101116.
3
Medical Countermeasures against Ricin Intoxication.抗蓖麻毒素医疗对策。
Toxins (Basel). 2023 Jan 20;15(2):100. doi: 10.3390/toxins15020100.
4
Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine.热稳定冻干单价疫苗诱导蓖麻毒素的持久免疫力。
mSphere. 2021 Dec 22;6(6):e0075021. doi: 10.1128/mSphere.00750-21. Epub 2021 Nov 3.
5
An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation.经鼻给药的单克隆抗体鸡尾酒可消除蓖麻毒素诱导的肺组织损伤和炎症。
Hum Vaccin Immunother. 2020 Apr 2;16(4):793-807. doi: 10.1080/21645515.2019.1664243. Epub 2019 Oct 29.
6
Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes.枯否细胞和肝窦内皮细胞对蓖麻毒素和蓖麻毒素-Ab 复合物的敏感性。
J Leukoc Biol. 2019 Nov;106(5):1161-1176. doi: 10.1002/JLB.4A0419-123R. Epub 2019 Jul 16.
7
A New Method for Extraction and Analysis of Ricin Samples through MALDI-TOF-MS/MS.通过 MALDI-TOF-MS/MS 进行蓖麻毒素样本的提取和分析的新方法。
Toxins (Basel). 2019 Apr 3;11(4):201. doi: 10.3390/toxins11040201.
8
Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine.冻干粉化蓖麻毒素毒素亚单位疫苗的热稳定性和抗原表位完整性。
Vaccine. 2018 Sep 25;36(40):5967-5976. doi: 10.1016/j.vaccine.2018.08.059. Epub 2018 Aug 29.
9
Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication.α-半乳糖神经酰胺（αGalCer）增强蓖麻毒素中毒模型中的疫苗诱导保护作用。
Hum Vaccin Immunother. 2018;14(8):2053-2057. doi: 10.1080/21645515.2018.1461299. Epub 2018 May 14.
10
High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.候选蓖麻毒素亚单位疫苗RiVax上四个空间上不同的中和表位簇的高清图谱
Clin Vaccine Immunol. 2017 Dec 5;24(12). doi: 10.1128/CVI.00237-17. Print 2017 Dec.
本文引用的文献
1
Structure of RiVax: a recombinant ricin vaccine.RiVax的结构：一种重组蓖麻毒素疫苗。
Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):826-30. doi: 10.1107/S0907444911026771. Epub 2011 Aug 9.
2
Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication.皮内给药 RiVax 可保护小鼠免受粘膜和全身蓖麻毒素中毒。
Vaccine. 2010 Jul 19;28(32):5315-22. doi: 10.1016/j.vaccine.2010.05.045. Epub 2010 Jun 1.
3
A pilot clinical trial of a recombinant ricin vaccine in normal humans.重组蓖麻毒素疫苗在正常人体中的初步临床试验。
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2268-73. doi: 10.1073/pnas.0510893103. Epub 2006 Feb 3.
4
Preclinical toxicity and efficacy testing of RiVax, a recombinant protein vaccine against ricin.抗蓖麻毒素重组蛋白疫苗RiVax的临床前毒性和疗效测试。
Vaccine. 2005 Sep 15;23(39):4775-84. doi: 10.1016/j.vaccine.2005.04.037.
5
The history of ricin, abrin and related toxins.蓖麻毒素、相思子毒素及相关毒素的历史。
Toxicon. 2004 Sep 15;44(4):361-70. doi: 10.1016/j.toxicon.2004.05.003.
6
A dominant linear B-cell epitope of ricin A-chain is the target of a neutralizing antibody response in Hodgkin's lymphoma patients treated with an anti-CD25 immunotoxin.蓖麻毒素A链的一个显性线性B细胞表位是接受抗CD25免疫毒素治疗的霍奇金淋巴瘤患者中中和抗体反应的靶点。
Clin Exp Immunol. 2004 May;136(2):365-72. doi: 10.1111/j.1365-2249.2004.02442.x.
7
Adverse events after immunisation with aluminium-containing DTP vaccines: systematic review of the evidence.含铝白喉破伤风百日咳疫苗免疫后的不良事件：证据的系统评价
Lancet Infect Dis. 2004 Feb;4(2):84-90. doi: 10.1016/S1473-3099(04)00927-2.
8
A novel recombinant vaccine which protects mice against ricin intoxication.一种新型重组疫苗，可保护小鼠免受蓖麻毒素中毒。
Vaccine. 2002 Sep 10;20(27-28):3422-7. doi: 10.1016/s0264-410x(02)00312-2.
9
Overview of vaccine adjuvants: present and future.疫苗佐剂概述：现状与未来
Vaccine. 2002 May 31;20 Suppl 3:S7-12. doi: 10.1016/s0264-410x(02)00164-0.
10
Biodefense. Peering into the shadows: Iraq's bioweapons program.生物防御。窥探阴影：伊拉克的生物武器计划。
Science. 2002 Aug 16;297(5584):1110-2. doi: 10.1126/science.297.5584.1110.
Zotero 插件