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本文引用的文献

1
Structure of RiVax: a recombinant ricin vaccine.RiVax的结构：一种重组蓖麻毒素疫苗。
Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):826-30. doi: 10.1107/S0907444911026771. Epub 2011 Aug 9.
2
Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication.皮内给药 RiVax 可保护小鼠免受粘膜和全身蓖麻毒素中毒。
Vaccine. 2010 Jul 19;28(32):5315-22. doi: 10.1016/j.vaccine.2010.05.045. Epub 2010 Jun 1.
3
A pilot clinical trial of a recombinant ricin vaccine in normal humans.重组蓖麻毒素疫苗在正常人体中的初步临床试验。
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2268-73. doi: 10.1073/pnas.0510893103. Epub 2006 Feb 3.
4
Preclinical toxicity and efficacy testing of RiVax, a recombinant protein vaccine against ricin.抗蓖麻毒素重组蛋白疫苗RiVax的临床前毒性和疗效测试。
Vaccine. 2005 Sep 15;23(39):4775-84. doi: 10.1016/j.vaccine.2005.04.037.
5
The history of ricin, abrin and related toxins.蓖麻毒素、相思子毒素及相关毒素的历史。
Toxicon. 2004 Sep 15;44(4):361-70. doi: 10.1016/j.toxicon.2004.05.003.
6
A dominant linear B-cell epitope of ricin A-chain is the target of a neutralizing antibody response in Hodgkin's lymphoma patients treated with an anti-CD25 immunotoxin.蓖麻毒素A链的一个显性线性B细胞表位是接受抗CD25免疫毒素治疗的霍奇金淋巴瘤患者中中和抗体反应的靶点。
Clin Exp Immunol. 2004 May;136(2):365-72. doi: 10.1111/j.1365-2249.2004.02442.x.
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Adverse events after immunisation with aluminium-containing DTP vaccines: systematic review of the evidence.含铝白喉破伤风百日咳疫苗免疫后的不良事件：证据的系统评价
Lancet Infect Dis. 2004 Feb;4(2):84-90. doi: 10.1016/S1473-3099(04)00927-2.
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A novel recombinant vaccine which protects mice against ricin intoxication.一种新型重组疫苗，可保护小鼠免受蓖麻毒素中毒。
Vaccine. 2002 Sep 10;20(27-28):3422-7. doi: 10.1016/s0264-410x(02)00312-2.
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Overview of vaccine adjuvants: present and future.疫苗佐剂概述：现状与未来
Vaccine. 2002 May 31;20 Suppl 3:S7-12. doi: 10.1016/s0264-410x(02)00164-0.
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Biodefense. Peering into the shadows: Iraq's bioweapons program.生物防御。窥探阴影：伊拉克的生物武器计划。
Science. 2002 Aug 16;297(5584):1110-2. doi: 10.1126/science.297.5584.1110.

铝佐剂吸附重组蓖麻毒素疫苗的1B期临床试验

Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine.

作者信息

Vitetta Ellen S, Smallshaw Joan E, Schindler John

机构信息

Cancer Immunobiology Center, University of Texas Southwestern Medical School, Dallas, USA.

出版信息

Clin Vaccine Immunol. 2012 Oct;19(10):1697-9. doi: 10.1128/CVI.00381-12. Epub 2012 Aug 22.

DOI:10.1128/CVI.00381-12
PMID:22914366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3485895/
Abstract

There is no FDA-approved vaccine for the potent plant toxin ricin. We have developed a recombinant ricin vaccine, RiVax. Without adjuvant it is safe and immunogenic in mice, rabbits, and humans. Based on our studies in mice, we now report the results of a small clinical trial with Alhydrogel-adsorbed RiVax.

摘要

目前尚无美国食品药品监督管理局（FDA）批准的针对强效植物毒素蓖麻毒素的疫苗。我们研发了一种重组蓖麻毒素疫苗RiVax。在无佐剂的情况下，它在小鼠、兔子和人类中均安全且具有免疫原性。基于我们在小鼠身上的研究，我们现在报告一项关于氢氧化铝吸附型RiVax的小型临床试验结果。