Center for Women's Reproductive Health, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University, New York, NY 10019, USA.
Hum Reprod. 2012 Nov;27(11):3321-7. doi: 10.1093/humrep/des280. Epub 2012 Aug 21.
Vitamin D plays a role in reproductive capacity. Recently, several investigators have demonstrated higher IVF pregnancy rates in vitamin D replete women. The objective of this study was to validate these findings and to further elucidate the role of vitamin D in reproduction among a diverse group of women.
This was a retrospective cohort study in an academic tertiary care center of 188 infertile women undergoing IVF. Serum levels of vitamin D (25OH-D) were measured in previously frozen serum samples. The main outcome measure was clinical pregnancy, defined as sonographic presence of a heartbeat following IVF.
The relationship between vitamin D status and pregnancy rates differed by race (P < 0.01). Among non-Hispanic whites, pregnancy rates declined with progressively lower levels of vitamin D, while in Asians, the reverse was true. Adjusting for age and number and quality of embryos transferred among non-Hispanic whites, the odds of pregnancy were four times higher in vitamin D replete versus deficient patients. Live birth rates mirrored pregnancy rates. Vitamin D status was not associated with ovarian stimulation parameters or with markers of embryo quality.
Vitamin D deficiency is associated with lower pregnancy rates in non-Hispanic whites, but not in Asians, possibly due to their lower IVF success rates. Vitamin D deficiency was not correlated with ovarian stimulation parameters or with markers of embryo quality, suggesting its effect may be mediated through the endometrium.
维生素 D 在生育能力方面发挥作用。最近，一些研究人员已经证明，维生素 D 充足的女性进行体外受精 (IVF) 的妊娠率更高。本研究的目的是验证这些发现，并进一步阐明维生素 D 在不同女性群体中的生殖作用。
这是在一家学术性三级保健中心对 188 名接受 IVF 的不孕女性进行的回顾性队列研究。在之前冷冻的血清样本中测量血清维生素 D（25OH-D）水平。主要观察指标是临床妊娠，定义为 IVF 后超声检查存在心跳。
维生素 D 状态与妊娠率的关系因种族而异（P < 0.01）。在非西班牙裔白种人中，随着维生素 D 水平的逐渐降低，妊娠率下降，而在亚洲人中，情况则相反。在非西班牙裔白种人中，调整年龄、移植胚胎数量和质量后，维生素 D 充足患者的妊娠几率是维生素 D 缺乏患者的四倍。活产率反映了妊娠率。维生素 D 状态与卵巢刺激参数或胚胎质量标志物无关。
维生素 D 缺乏与非西班牙裔白种人的妊娠率降低有关，但与亚洲人无关，这可能是由于他们的 IVF 成功率较低。维生素 D 缺乏与卵巢刺激参数或胚胎质量标志物无关，表明其作用可能通过子宫内膜介导。
